About: Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
Creator	Chen, Yang Gu, Zhongkai Jiang, Ju Liu, Xiaolong Wu, Xiaomo Zhang, Jinyan
Source	Medline; PMC
abstract	Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic fibroblast-like cells that can differentiate into cells of multiple lineages, such as chondrocytes, osteoblasts, adipocytes, myoblasts, and others. These multipotent MSCs can be found in nearly all tissues but mostly located in perivascular niches, playing a significant role in tissue repair and regeneration. Additionally, MSCs interact with immune cells both in innate and adaptive immune systems, modulating immune responses and enabling immunosuppression and tolerance induction. Understanding the biology of MSCs and their roles in clinical treatment is crucial for developing MSC-based cellular therapy for a variety of pathological conditions. Here, we review the progress in the study on the mechanisms underlying the immunomodulatory and regenerative effects of MSCs; update the medical translation of MSCs, focusing on the registration trials leading to regulatory approvals; and discuss how to improve therapeutic efficacy and safety of MSC applications for future.
has issue date	2020-08-08(xsd:dateTime)
bibo:doi	10.1186/s13287-020-01855-9
bibo:pmid	32771052
has license	cc-by
sha1sum (hex)	15d07be05f6ef52a4d64f181441d8da3647cc210
schema:url	https://doi.org/10.1186/s13287-020-01855-9
resource representing a document's title	Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
has PubMed Central identifier	PMC7414268
has PubMed identifier	32771052
schema:publication	Stem Cell Res Ther
resource representing a document's body	covid:15d07be05f6ef52a4d64f181441d8da3647cc210#body_text
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