About: MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

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About: MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6
Creator	Wang, Jianhua Feng, Yong Hou, Wei Chen, Lang Yu, Ting Zeng, Yan Hu, Haitao Ju, Zhao Wang, Meirong Xie, Linlin Xiong, Hairong Zhong, Chaojie
Source	PMC
abstract	BACKGROUND: The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preventing uncoating, the nuclear import of pre-integration complex (PIC) and viral DNA integration. This work explores the mechanisms of MxB-mediated HIV-1 inhibition. RESULTS: We demonstrated that MxB represses NUP358-mediated PIC nuclear import and HIV-1 replication. Moreover, MxB’s effects on PIC nuclear import and HIV-1 replication depend critically on cofactor cleavage and polyadenylation specificity factor subunit 6 (CPSF6). MxB binds nucleoporin NUP358, blocks NUP358-CA interaction, thereby impeding the nuclear import of HIV-1 PIC with CPSF6 binding to PIC. More intriguingly, CPSF6’s role in nuclear import depends on MxB, being a facilitator of HIV-1 nuclear import on its own, but becoming an inhibitor when MxB is present. CONCLUSIONS: Our work establishes that MxB impedes the NUP358-mediated HIV-1 nuclear import and viral replication cooperatively with CPSF6.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1186/s12977-020-00524-2
has license	no-cc
sha1sum (hex)	156b408dabc8aa1d5147b11878420f43b83fd1b5
schema:url	https://doi.org/10.1186/s12977-020-00524-2
resource representing a document's title	MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6
has PubMed Central identifier	PMC7322711
schema:publication	Retrovirology
resource representing a document's body	covid:156b408dabc8aa1d5147b11878420f43b83fd1b5#body_text
is schema:about of	named entity 'PIC' named entity 'pre-integration complex' named entity 'viral replication' named entity 'nuclear import' named entity 'mediated' covid:arg/156b408dabc8aa1d5147b11878420f43b83fd1b5 named entity 'replication' named entity 'HIV-1' named entity 'HIV-1' named entity 'protein' named entity 'PIC' named entity 'pre-integration complex' named entity 'NUP358' named entity 'HIV-1' named entity 'PIC' named entity 'NUP358' named entity 'vector' named entity 'nuclear import' named entity 'streptomycin' named entity 'HIV-1' named entity 'nuclear pore' named entity 'Statistical significance' named entity 'lysis buffer' named entity 'CPSF6' named entity 'phenotypes' named entity 'integrase' named entity 'NUP98' named entity 'cloned' named entity 'HIV-1' named entity 'antiviral' named entity 'CPSF6' named entity 'CPSF6' named entity 'plasmids' named entity 'Hemagglutinin' named entity 'PIC' named entity 'colocalization' named entity 'paraformaldehyde' named entity 'viral replication' named entity 'HIV-1' named entity 'NUP358' named entity 'HIV-1' named entity 'Immunoprecipitation' named entity 'plasmids' named entity 'nuclear import' named entity 'Assay' named entity 'nuclear import' named entity 'HIV-1' named entity 'nuclear import' named entity 'incubation' named entity 'siRNA' named entity 'colocalization' named entity 'nucleoporins' named entity 'Protein' named entity 'nucleoporins' named entity 'NUP358' named entity 'Infectivity' named entity 'NIH' named entity 'infection' named entity 'biochemical' named entity 'PIC' named entity 'infection' named entity 'HeLa' named entity 'CPSF6' named entity 'N-terminal' named entity 'viral replication' named entity 'HIV-1' named entity 'host cell' named entity 'HIV-1' named entity 'antiviral activity' named entity 'HIV-1' named entity 'NUP358' named entity 'transfected'

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