About: Classification of self-assembling protein nanoparticle architectures for applications in vaccine design

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Classification of self-assembling protein nanoparticle architectures for applications in vaccine design Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Classification of self-assembling protein nanoparticle architectures for applications in vaccine design
Creator	Twarock, R Burkhard, P Indelicato, G
Source	Medline; PMC
abstract	We introduce here a mathematical procedure for the structural classification of a specific class of self-assembling protein nanoparticles (SAPNs) that are used as a platform for repetitive antigen display systems. These SAPNs have distinctive geometries as a consequence of the fact that their peptide building blocks are formed from two linked coiled coils that are designed to assemble into trimeric and pentameric clusters. This allows a mathematical description of particle architectures in terms of bipartite (3,5)-regular graphs. Exploiting the relation with fullerene graphs, we provide a complete atlas of SAPN morphologies. The classification enables a detailed understanding of the spectrum of possible particle geometries that can arise in the self-assembly process. Moreover, it provides a toolkit for a systematic exploitation of SAPNs in bioengineering in the context of vaccine design, predicting the density of B-cell epitopes on the SAPN surface, which is critical for a strong humoral immune response.
has issue date	2017-04-26(xsd:dateTime)
bibo:doi	10.1098/rsos.161092
bibo:pmid	28484626
has license	cc-by
sha1sum (hex)	155de81e6f3c3ca342aa733e289b749a5394a26b
schema:url	https://doi.org/10.1098/rsos.161092
resource representing a document's title	Classification of self-assembling protein nanoparticle architectures for applications in vaccine design
has PubMed Central identifier	PMC5414263
has PubMed identifier	28484626
schema:publication	R Soc Open Sci
resource representing a document's body	covid:155de81e6f3c3ca342aa733e289b749a5394a26b#body_text
is schema:about of	named entity 'vaccine design' named entity 'self-assembly' named entity 'nanoparticles' named entity 'fullerene' named entity '3,5' named entity 'peptide' named entity 'vaccine design' named entity 'nanoparticle' named entity 'self-assembling' named entity 'vertex colouring' named entity 'vectors' named entity 'nanoparticle' named entity 'tetrahedral symmetry' named entity 'Nanoparticle' named entity 'virus' named entity 'fundamental domain' named entity 'nanoparticle' named entity 'Fullerenes' named entity 'icosahedral symmetry' named entity 'fullerene' named entity 'fullerene' named entity 'rhombic triacontahedron' named entity 'capsid protein' named entity 'nanoparticles' named entity 'antigen' named entity 'G.I.' named entity 'tetrahedral symmetry' named entity 'PBBs' named entity 'vertex colouring' named entity 'synthetic vaccines' named entity 'PBBs' named entity 'virology' named entity 'nanoparticle' named entity 'epitopes' named entity 'nanoparticle' named entity 'nanoparticle' named entity 'morphology' named entity 'SAPN' named entity 'vertex colouring' named entity 'nanoparticle' named entity 'α-helical' named entity 'fullerenes' named entity 'icosahedron' named entity 'capsid proteins' named entity '3.5' named entity 'combinatorial analysis' named entity 'vaccine design' named entity 'SARS' named entity 'CEO' named entity '7 nm' named entity 'tetrahedral symmetry' named entity 'biophysical' named entity 'epitope' named entity 'nanoparticle' named entity 'SAPN' named entity 'α, β' named entity 'hexagonal tessellation' named entity 'pentamer' named entity 'fullerene' named entity 'carbon' named entity 'pentamer' named entity 'SAPN' named entity 'B-cell' named entity 'chimeric forms' named entity 'SAPN' named entity 'P.B.' named entity 'viral capsids' named entity 'equilateral triangle' named entity 'coiled coil' named entity 'icosahedral group' named entity 'CCP4' named entity 'polypeptide' named entity 'fullerenes' named entity 'nanoparticle' named entity 'fullerene' named entity 'analytical ultracentrifugation' named entity 'spherical geometry' named entity 'nanoparticles' named entity 'fullerene'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software