About: Virus strain of a mild COVID-19 patient in Hangzhou representing a new trend in SARS-CoV-2 evolution related to Furin cleavage site

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About: Virus strain of a mild COVID-19 patient in Hangzhou representing a new trend in SARS-CoV-2 evolution related to Furin cleavage site Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus strain of a mild COVID-19 patient in Hangzhou representing a new trend in SARS-CoV-2 evolution related to Furin cleavage site
Creator	Wang, Xiaoyan Wu, Nanping Li, Lanjuan Sheng, Jifang Chen, Dong Yu, Liang Jia, Hongyu Hao, Shaorui Hu, Jianhua Yang, Yida Liang, Tingbo Wu, Haibo Yao, Hangping Zheng, Lin Zhang, Yimin Cheng, Linfang Gao, Jianguo Jiang, Penglei Jin, Changzhong Jin, Xi Lian, Jiangshan Liu, Fumin Lu, Xiangyun Lu, Yingfeng Ren, Yue Shen, Jian Wen, Liang Xiang, Dairong Xu, Kangli Yao, Jinmei Yu, Guodong Yu, Xiaopeng Zheng, Ruoheng
source	MedRxiv
abstract	We found, in our 788 confirmed COVID-19 patients, the decreased rate of severe/critical type, increased liver/kidney damage and prolonged period of nuclear acid positivity during virus dissemination, when compared with Wuhan. To investigate the underlining mechanism, we isolated one strain of SARS- CoV-2 (ZJ01) in mild COVID-19 patient and found the existence of 35 specific gene mutation by gene alignment. Further phylogenetic analysis and RSCU heat map results suggested that ZJ01 may be a potential evolutionary branch of SARS-CoV-2. We classified 54 strains of viruses worldwide (C/T type) based on the base (C or T) at positions 8824 and 28247. ZJ01 were both T at these two sites, becoming the only TT type currently identified in the world. The prediction of Furin cleavage site (FCS) and the sequence alignment of virus family indicated that FCS may be an important site of coronavirus evolution. ZJ01 had mutations near FCS (F1-2), which caused changes in the structure and the electrostatic distribution of the S protein surface, further affecting the binding capacity of Furin. Single cell sequencing and ACE2-Furin co-expression results confirmed that Furin level was higher in the whole body, especially in glands, liver, kidney and colon while FCS may help SARS-CoV-2 infect these organs. The evolutionary pattern of SARS-CoV-2 towards FCS formation may result in its clinical symptom becoming closer to HKU-1 and OC43 (the source of FCS sequence-PRRA) caused influenza, further showing potential in differentiating into mild COVID-19 subtypes.
has issue date	2020-03-13(xsd:dateTime)
bibo:doi	10.1101/2020.03.10.20033944
has license	medrxiv
sha1sum (hex)	14c2c535373fe6727127b820fb86f55d0f91a41d
schema:url	https://doi.org/10.1101/2020.03.10.20033944
resource representing a document's title	Virus strain of a mild COVID-19 patient in Hangzhou representing a new trend in SARS-CoV-2 evolution related to Furin cleavage site
resource representing a document's body	covid:14c2c535373fe6727127b820fb86f55d0f91a41d#body_text
is schema:about of	named entity 'caused' named entity 'type' named entity 'organs' named entity 'Single cell sequencing' named entity 'HKU' named entity 'COVID-19' named entity 'Furin' named entity 'virus' named entity 'Hangzhou' covid:arg/14c2c535373fe6727127b820fb86f55d0f91a41d named entity 'liver' named entity 'phylogenetic analysis' named entity 'type' named entity 'patients' named entity 'clinical symptom' named entity 'closer' named entity 'kidney' named entity 'structure' named entity 'FCS' named entity 'SARS-CoV-2' named entity 'FCS' named entity 'Furin' named entity 'infect' named entity 'potential' named entity 'site' named entity 'viruses' named entity 'Furin' named entity 'kidney' named entity 'COVID-19' named entity 'Furin' named entity 'Single cell sequencing' named entity 'heat map' named entity 'Furin' named entity 'SARS-CoV-2' named entity 'Wuhan' named entity 'SARS-CoV-2' named entity 'Hangzhou' named entity 'Virus strain' named entity 'SARS-CoV-2' named entity 'mutation' named entity 'SARS-CoV-2' named entity 'OC43' named entity 'feces' named entity 'preprint' named entity 'evolution' named entity 'SARS-CoV-2' named entity 'Furin' named entity 'virus' named entity 'March 13, 2020' named entity 'preprint' named entity 'liver' named entity 'Viruses' named entity 'TMPRSS2'

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