About: Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa

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About: Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
Creator	Tempia, Stefano Venter, Marietjie Cohen, Cheryl Treurnicht, Florette Walaza, Sibongile Dawood, Halima Moyes, Jocelyn Pretorius, Marthi Variava, Ebrahim Cohen, Adam Hellferscee, Orienka Madhi, Shabir Chhagan, Meera Haffjee, Sumayya
Source	PMC
abstract	BACKGROUND: Rhinoviruses (RV) are a well-established cause of respiratory illness. RV-C has been associated with more severe illness. We aimed to characterize and compare the clinical presentations and disease severity of different RV type circulating in South Africa. METHOD: We performed two analyses of RV-positive specimens identified through surveillance in South Africa across all age groups. First, RV-positive specimens identified through severe acute respiratory illness (SARI) surveillance in four provinces was randomly selected from 2009 to 2010 for molecular characterization. Second, RV-positive specimens identified through SARI, influenza-like illness (ILI) and control surveillance at hospitals and outpatient clinics in during 2012–2013 were used to determine the association of RV type with severe disease. Selected specimens were sequenced, and phylogenetic analysis was performed. RESULTS: Among the 599 sequenced specimens from 2009 to 2010 and 2012 to 2013, RV-A (285, 48%) and RV-C (247, 41%) were more commonly identified than RV-B (67, 11%), with no seasonality and a high genetic diversity. A higher prevalence of RV infection was identified in cases with SARI [515/962 (26%); aRRR = 1·6; 95% CI 1·21; 2·2] and ILI [356/962 (28%); aRRR = 1·9; 95% CI 1·37; 2·6] compared with asymptomatic controls (91/962, 22%). There was no difference in disease severity between the different type when comparing SARI, ILI and controls. CONCLUSION: All three type of RV were identified in South Africa, although RV-A and RV-C were more common than RV-B. RV was associated with symptomatic respiratory illness; however, there was no association between RV type and disease severity.
has issue date	2014-07-03(xsd:dateTime)
bibo:doi	10.1111/irv.12264
bibo:pmid	24990601
has license	cc-by
sha1sum (hex)	145c00618e7b5beab53921724359331022630804
schema:url	https://doi.org/10.1111/irv.12264
resource representing a document's title	Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
has PubMed Central identifier	PMC4181821
has PubMed identifier	24990601
schema:publication	Influenza Other Respir Viruses
resource representing a document's body	covid:145c00618e7b5beab53921724359331022630804#body_text
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