About: Virus-Induced Demyelination: The Case for Virus(es) in Multiple Sclerosis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Virus-Induced Demyelination: The Case for Virus(es) in Multiple Sclerosis
Creator	Jacobson, Steven Soldan, Samantha
source	PMC
abstract	Multiple Sclerosis (MS) is the most common demyelinating disease of man with over 400,000 cases in the United States and over 2.5 million cases worldwide. There are over 64,000 citations in Pubmed dating back as far as 1887. Much has been learned over the past 129 years with a recent burst in therapeutic options (mostly anti-inflammatory) with newer medications in development that are neuroprotective and/or neuroreparative. However, with all these advancements the cause of MS remains elusive. There is a clear interplay of genetic, immunologic, and environmental factors that influences both the development and progression of this disorder. This chapter will give a brief overview of the history and pathogenesis of MS with attention to how host immune responses in genetically susceptible individuals contribute to the MS disease process. In addition, we will explore the role of infectious agents in MS as potential “triggers” of disease. Models of virus-induced demyelination will be discussed, with an emphasis on the recent interest in human herpesviruses and the role they may play in MS disease pathogenesis. Although we remain circumspect as to the role of any microbial pathogen in MS, we suggest that only through well-controlled serological, cellular immune, molecular, and animal studies we will be able to identify candidate agents. Ultimately, clinical interventional trials that either target a specific pathogen or class of pathogens will be required to make definitive links between the suspected agent and MS.
has issue date	2016-04-08(xsd:dateTime)
bibo:doi	10.1007/978-3-319-33189-8_6
has license	no-cc
sha1sum (hex)	1426b0851e3e9b0d1c64f6ddea09781210ef2641
schema:url	https://doi.org/10.1007/978-3-319-33189-8_6
resource representing a document's title	Virus-Induced Demyelination: The Case for Virus(es) in Multiple Sclerosis
has PubMed Central identifier	PMC7122906
schema:publication	Neurotropic Viral Infections
resource representing a document's body	covid:1426b0851e3e9b0d1c64f6ddea09781210ef2641#body_text
is schema:about of	named entity 'Demyelination' named entity 'VIRUS' named entity 'MULTIPLE SCLEROSIS' named entity 'DEMYELINATION' named entity 'CASE' named entity 'INDUCED' named entity 'Virus' named entity 'Virus' named entity 'open reading frames' named entity 'CD46' named entity 'EBV' named entity 'viral infections' named entity 'Toll-like receptor 4' named entity 'evolution' named entity 'Copolymer' named entity 'MOG' named entity 'herpesviruses' named entity 'TMEV' named entity 'immune response' named entity 'HHV-6A' named entity 'CNS' named entity 'haplotypes' named entity 'demyelinating disease' named entity 'etiology' named entity 'class II' named entity 'EBV' named entity 'environmental factors' named entity 'genetic background' named entity 'immune responses' named entity 'macrophages' named entity 'HHV-5' named entity 'HHV-6A' named entity 'DRB1' named entity 'immune function' named entity 'cardiovascular' named entity 'HIV-1' named entity 'herpesviruses' named entity 'mitochondria' named entity 'HHV-6B' named entity 'steroids' named entity 'autoimmune disease' named entity 'cytokines' named entity 'demyelination' named entity 'CNS' named entity 'HHV-6' named entity 'measles virus' named entity 'neuropathology' named entity 'antiviral' named entity 'HHV-6A' named entity 'MBP' named entity 'RRMS' named entity 'asymptomatic carriers' named entity 'epitope spreading' named entity 'molecular mimicry' named entity 'virus infections' named entity 'astrocytes' named entity 'IL12' named entity 'IgM' named entity 'bacteria' named entity 'remyelination' named entity 'EBV' named entity 'SFV' named entity 'HHV-6' named entity 'CNS' named entity 'nasopharynx' named entity 'mice' named entity 'antibodies' named entity 'EBV' named entity 'antibiotic treatment' named entity 'HTLV-I' named entity 'monozygotic' named entity 'commensal' named entity 'EBV' named entity 'receptor' named entity 'gene' named entity 'HHV-6' named entity 'antigens' named entity 'viral infection' named entity 'HHV-6' named entity 'Rickinson' named entity 'glycoproteins' named entity 'serum'

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