About: IFN-γ– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis

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About: IFN-γ– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IFN-γ– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis
Creator	Zhao, Jincun Perlman, Stanley Zhao, Jingxian Fett, Craig Fleming, Erica Trandem, Kathryn
Source	Medline; PMC
abstract	Foxp3(+) CD4 regulatory T cells (T reg cells) are important in limiting immunopathology in infections. However, identifying pathogen-specific epitopes targeted by these cells has been elusive. Using MHC class II/peptide tetramers and intracellular cytokine staining, we identify T reg cells recognizing two virus-specific CD4 T cell epitopes in the coronavirus-infected central nervous system as well as naive T cell precursor pools. These T reg cells are detected at the same time as effector T cells (T eff cells) exhibiting the same specificity and can suppress T eff cell proliferation after stimulation with cognate peptide. These virus-specific T reg cells may be especially effective in inhibiting the immune response during the peak of infection, when virus antigen is maximal. Furthermore, these T reg cells express both IL-10 and IFN-γ after peptide stimulation. IFN-γ expression is maintained during both acute and chronic phases of infection. Identification of T reg cell target epitopes by cytokine production is also applicable in autoimmune disease because myelin oligodendrocyte glycoprotein–specific Foxp3(+) T reg cells express IL-10 and IL-17 at the peak of disease in mice with experimental autoimmune encephalomyelitis. These results show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
has issue date	2011-08-01(xsd:dateTime)
bibo:doi	10.1084/jem.20110236
bibo:pmid	21746812
has license	cc-by-nc-sa
sha1sum (hex)	13e6c9b0730b53139910cfa6835ae4c460a30851
schema:url	https://doi.org/10.1084/jem.20110236
resource representing a document's title	IFN-γ– and IL-10–expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis
has PubMed Central identifier	PMC3149215
has PubMed identifier	21746812
schema:publication	J Exp Med
resource representing a document's body	covid:13e6c9b0730b53139910cfa6835ae4c460a30851#body_text
is schema:about of	named entity 'expressing' named entity 'virus' named entity 'central nervous system' named entity 'Foxp3' named entity 'IL-10' named entity 'ENCEPHALOMYELITIS' named entity 'SPECIFIC' named entity 'CELLS' named entity 'VIRUS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'IFN' named entity 'FOXP3' named entity 'EPITOPE' named entity 'T REG' named entity 'reg' named entity 'epitope' named entity 'IL-10' named entity 'encephalomyelitis' named entity 'M133' named entity 'epitopes' named entity 'CNS' named entity 'CNS tissue' named entity 'cDNA' named entity 'virus' named entity 'Seattle' named entity 'Foxp3' named entity 'IFN' named entity 'TCR' named entity 'infection' named entity 'mice' named entity 'infection' named entity 'staining' named entity 'acute encephalitis' named entity 'gfp' named entity 'protein' named entity 'IFN' named entity 'IL-2' named entity 'CD4 T cells' named entity 'Intracellular' named entity 'IFN' named entity 'PerCP' named entity 'IFN' named entity 'Invitrogen' named entity 'mice' named entity 'peptide' named entity 'Th1-type' named entity 'CD4 +' named entity 'effector T cells' named entity 'Foxp3' named entity 'IFN' named entity 'T-bet' named entity 'M133' named entity 'autoimmune disease' named entity 'virus' named entity 'epitope' named entity 'emulsion' named entity 'clinical symptoms' named entity 'Foxp3' named entity 'intravenously' named entity 'recombinant' named entity 'TCR' named entity 'TCR' named entity 'effector' named entity 'IL-10' named entity 'effector' named entity 'infection' named entity 'Foxp3' named entity 'cell lines' named entity 'NOD mice' named entity 'effector T cells' named entity 'infection' named entity 'Mononuclear cells' named entity 'Toxoplasma gondii' named entity 'spinal cords' named entity 'mice' named entity 'MHC'

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