About: Middle East respiratory syndrome coronavirus intermittent positive cases: Implications for infection control

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Middle East respiratory syndrome coronavirus intermittent positive cases: Implications for infection control
Creator	Memish, Ziad Al-Tawfiq, Jaffar Alfaraj, Sarah
Source	Elsevier; Medline; PMC
abstract	Background Middle East respiratory syndrome coronavirus (MERS-CoV) continues to be reported from the Kingdom of Saudi Arabia. Data on the phenomenon of intermittent positive results for MERS-CoV on reverse-transcription polymerase chain reaction (RT-PCR) with negative results in between are lacking. Here we describe cases with intermittent positive MERS-CoV test results and highlight the required number of tests to rule out or rule in MERS-CoV infection based on a large retrospective cohort of patients with confirmed MERS-CoV. Methods This analysis included cases admitted between January 2014 and December 2017. The included patients had a minimum of 3 nasopharyngeal MERS-CoV RT-PCR tests for confirmation and needed 2 negative samples for MERS-CoV evaluated 48 hours apart with clinical improvement or stabilization apart to ensure clearance. Results A total of 408 patients with positive MERS-CoV test results were treated at the referring hospital. We excluded 72 patients who had only 1 swab result available in the system and were treated in the initial years of the disease. Of the remaining 336 patients, 300 (89%) had a positive result after 1 swab, 324 (96.5%) had a positive result after 2 consecutive swabs, and 328 (97.6%) had a positive result after 3 consecutive swabs. Of the total cases, 46 (13.7%) had a positive MERS-CoV test then a negative test, followed by positive test results. Conclusions Our data indicate that 2 to 3 nasopharyngeal samples are needed to produce the highest yield of positive results for MERS-CoV. In addition, 2 negative results 48 hours apart with clinical improvement or stabilization are needed to clear patients from MERS-CoV. Evaluation of the yield of sputum samples is needed to assess the effectiveness against nasopharyngeal swabs.
has issue date	2019-03-31(xsd:dateTime)
bibo:doi	10.1016/j.ajic.2018.08.020
bibo:pmid	30352694
has license	els-covid
sha1sum (hex)	13bfa7a8290098863360920e13cd2c76b12456a8
schema:url	https://doi.org/10.1016/j.ajic.2018.08.020
resource representing a document's title	Middle East respiratory syndrome coronavirus intermittent positive cases: Implications for infection control
has PubMed Central identifier	PMC7115256
has PubMed identifier	30352694
schema:publication	American Journal of Infection Control
resource representing a document's body	covid:13bfa7a8290098863360920e13cd2c76b12456a8#body_text
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