About: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

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About: Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
Creator	Iwasaki, Akiko Alfajaro, Mia Wilen, Craig Dong, Huiping Homer, Robert Israelow, Benjamin Liu, Feimei Lu, Peiwen Mao, Tianyang Meir, Amit Ring, Aaron Song, Eric Wei, Jin
Source	Medline; PMC
abstract	Severe acute respiratory syndrome–coronavirus 2 (SARS-Cov-2) has caused over 13,000,000 cases of coronavirus disease (COVID-19) with a significant fatality rate. Laboratory mice have been the stalwart of therapeutic and vaccine development; however, they do not support infection by SARS-CoV-2 due to the virus’s inability to use the mouse orthologue of its human entry receptor angiotensin-converting enzyme 2 (hACE2). While hACE2 transgenic mice support infection and pathogenesis, these mice are currently limited in availability and are restricted to a single genetic background. Here we report the development of a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)–mediated expression of hACE2. These mice support viral replication and exhibit pathological findings found in COVID-19 patients. Moreover, we show that type I interferons do not control SARS-CoV-2 replication in vivo but are significant drivers of pathological responses. Thus, the AAV-hACE2 mouse model enables rapid deployment for in-depth analysis following robust SARS-CoV-2 infection with authentic patient-derived virus in mice of diverse genetic backgrounds.
has issue date	2020-08-04(xsd:dateTime)
bibo:doi	10.1084/jem.20201241
bibo:pmid	32750141
has license	cc-by-nc-sa
sha1sum (hex)	136b9c0aa6ffaee97318814efa2e63dfbf9993ba
schema:url	https://doi.org/10.1084/jem.20201241
resource representing a document's title	Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling
has PubMed Central identifier	PMC7401025
has PubMed identifier	32750141
schema:publication	J Exp Med
resource representing a document's body	covid:136b9c0aa6ffaee97318814efa2e63dfbf9993ba#body_text
is schema:about of	named entity 'mice' named entity 'angiotensin-converting enzyme 2' named entity 'stalwart' named entity 'mice' named entity 'SARS-CoV-2' named entity 'cases' named entity 'authentic' named entity 'genetic' named entity 'genetic' named entity 'vivo' named entity 'mouse' named entity 'While' named entity 'Mouse' named entity 'SARS-CoV-2' named entity 'genetic background' named entity 'infection' named entity 'Laboratory mice' named entity 'type I interferons' named entity 'virus' named entity 'infection' named entity 'coronavirus 2' named entity 'genetic backgrounds' named entity 'mice' named entity 'type I interferon' named entity 'SARS-CoV-2' named entity 'coronavirus' named entity 'SARS-CoV-2' named entity 'SARS' named entity 'IFN' named entity 'monocyte-derived macrophages' named entity 'natural killer (NK) cells' named entity 'monocyte' named entity 'lung' named entity 'antibody response' named entity 'IFNAR' named entity 'IRF3' named entity 'FACS' named entity 'fluorochrome' named entity 'IFN' named entity 'neutrophils' named entity 'virus' named entity 'isoflurane' named entity 'Sia' named entity 'vaccines' named entity 'autopsy' named entity 'trachea' named entity 'adenoviral vector' named entity 'SARS-CoV-2' named entity 'SARS-CoV' named entity 'sulfuric acid' named entity 'bead' named entity 'transcriptome' named entity 'COVID' named entity 'antiviral' named entity 'pathologist' named entity 'serum' named entity 'IFNAR' named entity 'BD Biosciences' named entity 'epithelia' named entity 'genetic backgrounds' named entity 'IRF3' named entity 'immunopathology' named entity 'Abcam' named entity 'endogenous' named entity 'lung tissue' named entity 'infection' named entity 'type I IFN' named entity 'IFN' named entity 'SARS-CoV-2'

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