About: Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013

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About: Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017 Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017
Creator	Zarrilli, Raffaele Dolce, Pasquale Esposito, Eliana Raimondi, Francesco Scamardo, Marina Triassi, Maria
Source	PMC
abstract	BACKGROUND: Healthcare-associated infections (HAIs) occur frequently in intensive care units (NICUs). The aim of this study was to analyze the results of surveillance of HAIs in a III level NICU in Naples, Italy during 2013–2017 and to compare with those obtained during 2006–2010. METHODS: The surveillance included 1265 neonates of all birth weight (BW) classes with > 2 days NICU stay. Infections were defined using standard Centers for Disease Control and Prevention definitions adapted to neonatal pathology. RESULTS: A total of 125 HAIs were registered during 2013–2017 with a frequency of 9.9% and an incidence density of 3.2 per 1000 patient days. HAIs occurred in all BW classes with a decreasing trend from the lowest to the highest BW classes (p = < 0.001). Central line-associated blood stream infection (CLABSI) was the most frequent infection (69.6%), followed by ventilator associated pneumonia (VAP) (20%), urinary tract infection (UTI) (8.8%) and necrotizing enterocolitis (NEC) (1.6%). Also, CLABSI and VAP incidence density decreased from lower to highest BW classes showing a significant trend (p = 0.007). Most frequent pathogens responsible for CLABSI were: Coagulase-negative staphylococci (CONS) (25.3%), Candida parapsilosis (21.8%), Pseudomonas aeruginosa (5.7), Escherichia coli and Klebsiella pneumoniae (6.8%). No microbiological diagnosis was achieved for 20.7% of CLABSI. Pseudomonas aeruginosa (28%), Stenotrophomonas maltophilia (20%), and CONS (20%) were the most frequent pathogens responsible for VAP. CLABSI incidence density showed no differences between 2006 and 2010 and 2013–2017, while VAP incidence density for the 751–100 g BW class was higher during 2006–2010 than during 2013–2017 (p = 0.006). A higher incidence of the CLABSI caused by Gram positive bacteria (p = 0.002) or by undetermined etiology (p = 0.01) was observed during 2013–2017 than during 2006–2010, while a significant lower incidence of VAP caused by Gram-negative bacteria was found during 2013–2017 than during 2006–2010 (p = 0.007). CONCLUSION: HAIs in the NICU developed in all BW classes with a decreasing trend from the lowest to the highest BW classes in both study periods. Differences in the aetiology of CLABSI and VAP were found between the two study periods. This reinforces the importance of HAIs surveillance protocol in the NICU, which monitors microbiological isolates and use of medical devices for all BW classes of neonates.
has issue date	2020-03-18(xsd:dateTime)
bibo:doi	10.1186/s13052-020-0799-3
bibo:pmid	32183842
has license	cc-by
sha1sum (hex)	13557d309d24e6429459e469cf5a3e717083e3b0
schema:url	https://doi.org/10.1186/s13052-020-0799-3
resource representing a document's title	Trends, risk factors and outcomes of healthcare-associated infections in a neonatal intensive care unit in Italy during 2013–2017
has PubMed Central identifier	PMC7079437
has PubMed identifier	32183842
schema:publication	Ital J Pediatr
resource representing a document's body	covid:13557d309d24e6429459e469cf5a3e717083e3b0#body_text
is schema:about of	named entity 'aim' named entity 'Background' named entity '2017' named entity 'Healthcare-associated infections' named entity 'infection rate' named entity '95% CI' named entity 'link function' named entity 'birth weight' named entity 'single center' named entity 'VAP' named entity 'bloodstream infections' named entity 'bloodstream infections' named entity 'Gram-negative bacteria' named entity 'pregnancy' named entity 'single center' named entity 'Healthcare-associated infections' named entity 'NICU' named entity 'microbiological' named entity 'UTIs' named entity 'intensive care units' named entity 'birth weight' named entity 'etiology' named entity 'infection' named entity 'urinary tract infections' named entity 'invasive procedures' named entity 'patient care' named entity 'pathogens' named entity 'infection control' named entity 'infection' named entity 'infection' named entity 'catheterization' named entity 'central line' named entity 'birth weight' named entity 'catheter' named entity 'catheter' named entity 'Italy' named entity 'infection rate' named entity 'NICU' named entity 'emergency service' named entity 'neonatal intensive care units' named entity 'Italian' named entity 'NICU' named entity 'etiology' named entity 'ICUs' named entity 'nosocomial' named entity '5 BW' named entity 'microbiological' named entity 'CLABSI' named entity 'CDC' named entity 'aetiologies' named entity 'NICU' named entity 'prospective cohort study' named entity 'central line' named entity 'statistical computing' named entity 'etiology' named entity 'VAP' named entity '5.7%' named entity 'NICU' named entity 'CLABSI' named entity 'Italy' named entity 'infection' named entity 'catheter' named entity 'aetiology' named entity 'neonates' named entity 'pediatric' named entity 'Candida spp' named entity 'Gram-positive bacteria' named entity 'Brazil' named entity 'mechanical ventilation' named entity 'Coagulase-negative staphylococci' named entity 'reference group' named entity 'link function' named entity 'cumulative incidence' named entity 'neonates' named entity 'CLABSI' named entity 'nosocomial pneumonia'

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