About: A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens

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About: A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens
Creator	Lupfer, Christopher Pastey, Manoj Mullen, Valerie Geller, Bruce Johnson, Rudd Mitev, Georgi Reese, Kaleb
Source	PMC
abstract	A cost-effective and efficacious influenza vaccine for use in commercial poultry farms would help protect against avian influenza outbreaks. Current influenza vaccines for poultry are expensive and subtype specific, and therefore there is an urgent need to develop a universal avian influenza vaccine. We have constructed a live bacterial vaccine against avian influenza by expressing a conserved peptide from the ectodomain of M2 antigen (M2e) on the surface of Lactococcus lactis (LL). Chickens were vaccinated intranasally with the lactococcal vaccine (LL-M2e) or subcutaneously with keyhole-limpet-hemocyanin conjugated M2e (KLH-M2e). Vaccinated and nonvaccinated birds were challenged with high pathogenic avian influenza virus A subtype H5N2. Birds vaccinated with LL-M2e or KLH-M2e had median survival times of 5.5 and 6.0 days, respectively, which were significantly longer than non-vaccinated birds (3.5 days). Birds vaccinated subcutaneously with KLH-M2e had a lower mean viral burden than either of the other two groups. However, there was a significant correlation between the time of survival and M2e-specific serum IgG. The results of these trials show that birds in both vaccinated groups had significantly (P < 0.05) higher median survival times than non-vaccinated birds and that this protection could be due to M2e-specific serum IgG.
has issue date	2013-05-22(xsd:dateTime)
bibo:doi	10.1155/2013/316926
bibo:pmid	23766929
has license	cc-by
sha1sum (hex)	134da4eba94dc9b9f03a9244d62aee56abe0de56
schema:url	https://doi.org/10.1155/2013/316926
resource representing a document's title	A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens
has PubMed Central identifier	PMC3674685
has PubMed identifier	23766929
schema:publication	Vet Med Int
resource representing a document's body	covid:134da4eba94dc9b9f03a9244d62aee56abe0de56#body_text
is schema:about of	named entity 'PROLONGS' named entity 'AVIAN INFLUENZA A VIRUS' named entity 'M2E' named entity '0.05' named entity '5.5' named entity 'PEPTIDE' named entity 'INFLUENZA VACCINE' named entity 'RESULTS' named entity 'HEMOCYANIN' named entity 'GROUPS' named entity 'LIVE' named entity 'SIGNIFICANT' named entity 'CONSERVED' named entity '0 DAYS' named entity 'AVIAN INFLUENZA VACCINE' named entity 'CONJUGATED' named entity 'CORRELATION' named entity 'SERUM' named entity '283' named entity 'DAYS' named entity 'LIMPET' named entity 'NON-' named entity 'SUBTYPE' named entity 'EITHER' named entity 'HIGH' named entity 'PATHOGENIC' named entity 'THESE' named entity 'USE' named entity 'AVIAN INFLUENZA' named entity 'INFLUENZA VACCINES' named entity 'URGENT' named entity 'ANTIGEN' named entity 'VACCINATED' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA' named entity 'SURVIVAL' named entity 'VACCINE' named entity 'SURFACE' named entity 'COMMERCIAL' named entity 'WAS A' named entity 'BACTERIAL VACCINE' named entity 'TIMES' named entity 'SURVIVAL' named entity 'POULTRY' named entity 'FARMS' named entity 'HELP' named entity 'PROTECTION' named entity 'SPECIFIC' named entity 'PEPTIDE' named entity 'NOVEL' named entity 'CHICKENS' named entity 'ANTIGEN' named entity 'COST' named entity 'MEAN' named entity 'EFFECTIVE' named entity 'AVIAN INFLUENZA VIRUS' named entity 'BIRDS' named entity 'CONSTRUCTED' named entity 'CHICKENS' named entity 'VACCINATED' named entity 'VIRAL BURDEN' named entity 'HAVE' named entity 'KEYHOLE' named entity 'COULD BE' named entity 'KLH' named entity 'DUE TO' named entity 'VACCINE' named entity 'OUTBREAKS' named entity 'UNIVERSAL' named entity 'IGG' named entity 'CURRENT' named entity 'ECTODOMAIN' named entity 'INFLUENZA VIRUS A SUBTYPE' named entity 'MEDIAN' named entity 'NEED' named entity 'LACTOCOCCUS LACTIS'

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