About: β(2)-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study

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About: β(2)-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	β(2)-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study
Creator	Liu, Zhouwen Wu, Pingsheng Woodward, Kimberly Carroll, Kecia Hartert, Tina Larkin, Emma Minton, Patricia Moore, Paul Islam, Jessica Reiss, Sara Summar, Marshall
Source	Medline; PMC
abstract	BACKGROUND: Despite the significant interest in β(2)-Adrenergic receptor (ADRB2) polymorphisms related to asthma, whether ADRB2 genetic variants are similarly associated with acute respiratory tract infections have not been studied. We hypothesized that genetic variants in ADRB2 associated with a response to asthma therapy during an asthma exacerbation were also associated with severity of acute respiratory tract infections. METHODS: To test this hypothesis, we genotyped 5 common polymorphisms in the promoter region and coding block of the ADRB2 gene (loci -2387, -2274, -1343, +46, and +79) from 374 Caucasian and African American term infants who were enrolled at the time of acute respiratory illness over four respiratory viral seasons. Severity of respiratory tract infections was measured using a bronchiolitis severity score (BSS; range = 0-12, clinically significant difference = 0.5) with a higher score indicating more severe disease. We assigned the promoter, coding and combined promoter and coding haplotypes to the unphased genotype data. The associations between each of these five single-nucleotide polymorphisms (SNPs) as well as the haplotypes and infant BSS were analyzed using nonparametric univariate analysis and multivariable proportional odds model separately in Caucasians and African Americans. RESULTS: There was no significant association between infant BSS and each of the SNPs in both Caucasians and African Americans. However, promoter haplotype CCA was associated with a decreased BSS in African Americans in a dose dependent manner. The median (interquartile range) BSS of infants with no copies of the CCA haplotype, one copy, and two copies of the CCA haplotype were 5.5 (2.0, 8.0), 4.0 (1.0, 7.5), and 3.0 (1.0, 4.0), respectively. This dose dependent relationship persisted after adjusting for infant age, gender, daycare exposure, secondhand smoke exposure, prior history of breastfeeding, siblings at home, and enrollment season (adjusted odds ratio: 0.59, 95 % confidence interval: 0.36, 0.98). There was no similar protective relationship of haplotype CCA on severity of respiratory tract infections identified in Caucasians. CONCLUSIONS: ADRB2 genotype may be predictive of severity of acute respiratory tract infections in African Americans, and potentially identify a subset of infants who may respond to beta-agonist therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12881-015-0229-3) contains supplementary material, which is available to authorized users.
has issue date	2015-09-14(xsd:dateTime)
bibo:doi	10.1186/s12881-015-0229-3
bibo:pmid	26369942
has license	cc-by
sha1sum (hex)	132e94687b6ac1d68f3a33dcf090bc6f5865bb98
schema:url	https://doi.org/10.1186/s12881-015-0229-3
resource representing a document's title	β(2)-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study
has PubMed Central identifier	PMC4570703
has PubMed identifier	26369942
schema:publication	BMC Med Genet
resource representing a document's body	covid:132e94687b6ac1d68f3a33dcf090bc6f5865bb98#body_text
is schema:about of	named entity 'INFANCY' named entity 'PROSPECTIVE COHORT STUDY' named entity 'infants' named entity 'siblings' named entity 'There' named entity 'dose' named entity 'respiratory tract' named entity 'prospective cohort study' named entity 'PROMOTER' named entity 'RANGE' named entity 'SEVERITY' named entity 'SNPS' named entity 'AGE' named entity 'THESE' named entity 'BACKGROUND' named entity '7.5' named entity 'POLYMORPHISMS' named entity 'PROMOTER' named entity 'ADRB2' named entity 'DECREASED' named entity 'PRIOR' named entity '0.36' named entity 'COMMON' named entity '282' named entity 'EXPOSURE' named entity 'ASTHMA' named entity 'USING' named entity 'SEASON' named entity 'SEVERITY' named entity 'HAPLOTYPE' named entity 'REGION' named entity 'SIBLINGS' named entity 'GENOTYPE' named entity 'ODDS' named entity 'GENDER' named entity 'SEASONS' named entity 'INFANTS' named entity 'AT HOME' named entity 'HIGHER' named entity 'ACUTE' named entity 'ACUTE RESPIRATORY ILLNESS' named entity 'AFRICAN AMERICANS' named entity 'HISTORY OF' named entity 'WITH SEVERITY' named entity 'CODING' named entity 'INFANT' named entity 'CCA' named entity 'BRONCHIOLITIS' named entity 'RELATED' named entity 'IDENTIFIED' named entity 'THERAPY' named entity 'DOSE' named entity 'RESPONSE TO' named entity 'CONFIDENCE INTERVAL' named entity 'ENROLLED' named entity 'MODEL' named entity 'BLOCK' named entity 'BREASTFEEDING' named entity 'ASSOCIATION' named entity 'ADRENERGIC RECEPTOR' named entity '0.59' named entity 'TERM' named entity 'RESULTS' named entity 'HAVE' named entity 'AFRICAN AMERICAN' named entity 'UNIVARIATE ANALYSIS' named entity 'CAUCASIANS' named entity 'MEASURED' named entity 'DIFFERENCE' named entity 'SEVERITY SCORE' named entity 'HYPOTHESIS'

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