About: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs

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About: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
Creator	Byun, Jae-Kyung Cho, Mi-La Kim, Ho-Youn Moon, Young-Mee Park, Jin-Sil Park, Sung-Hwan Seo, Hyeon-Beom Lee, Seung Jhun, Jooyeon Jung, Kyungah
Source	PMC
abstract	PTEN is a tyrosine phosphatase with significant function in inhibiting STAT3 activation. Recently, inactivation of STAT3 has been demonstrated as a therapeutic candidate for autoimmune arthritis. The expression of PTEN controlled by p53 regulates autoimmune arthritis through modulating the balance between Th17 and Treg. We hypothesized that PTEN regulated by p53 might reduce CIA severity and inflammatory response via inhibiting STAT3 activation. Our results revealed that PTEN could ameliorate experimental autoimmune arthritis by reducing STAT3 activity and Th17 differentiation. Systemic infusion of PTEN overexpression downregulated CIA severity. In addition, PTEN overexpression decreased the activation of T cells and modulated reciprocal differentiation of Th17 and Treg cells. We observed that PTEN expression downregulated by p53 deficiency induced the activation of STAT3. Loss of p53 exacerbated autoimmune arthritis and dysregulated the population of Th17 and Treg. These data suggest that induction of STAT3-modulatory activity of PTEN may be a therapeutic target for rheumatoid arthritis therapy.
has issue date	2016-10-06(xsd:dateTime)
bibo:doi	10.1038/srep34617
bibo:pmid	27708408
has license	cc-by
sha1sum (hex)	131e6a035170ed5bd2dba6bec02649e9508a0c55
schema:url	https://doi.org/10.1038/srep34617
resource representing a document's title	PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs
has PubMed Central identifier	PMC5052580
has PubMed identifier	27708408
schema:publication	Sci Rep
resource representing a document's body	covid:131e6a035170ed5bd2dba6bec02649e9508a0c55#body_text
is schema:about of	named entity 'AUTOIMMUNE ARTHRITIS' named entity 'PTEN' named entity 'STAT3' named entity 'modulatory' named entity 'PTEN' named entity 'RECIPROCAL' named entity 'IS A' named entity 'DATA' named entity 'MODULATING' named entity 'LOSS OF' named entity 'TREG' named entity 'CONTROLLED BY' named entity 'INFLAMMATORY RESPONSE' named entity 'EXACERBATED' named entity 'ACTIVITY' named entity 'DIFFERENTIATION' named entity 'RESULTS' named entity 'CANDIDATE' named entity 'STAT3 ACTIVATION' named entity 'EXPRESSION' named entity 'INHIBITING' named entity 'OUR' named entity 'FUNCTION' named entity 'EXPERIMENTAL' named entity 'INFUSION' named entity 'TYROSINE PHOSPHATASE' named entity 'OBSERVED' named entity 'RHEUMATOID ARTHRITIS' named entity 'REVEALED' named entity 'ADDITION' named entity 'PTEN' named entity 'AUTOIMMUNE ARTHRITIS' named entity 'AMELIORATES' named entity 'CELLS' named entity 'INDUCED' named entity 'THESE' named entity 'DECREASED' named entity 'ARTHRITIS THERAPY' named entity 'SEVERITY' named entity 'BALANCE' named entity 'BALANCE' named entity 'REGULATING' named entity 'REDUCING' named entity 'TH17' named entity 'P53' named entity 'TH17' named entity 'THERAPEUTIC TARGET' named entity 'POPULATION' named entity 'REGULATED' named entity 'ACTIVATION' named entity 'DEFICIENCY' named entity 'INACTIVATION' named entity 'MODULATED' named entity 'T CELLS' named entity 'STAT3' named entity 'SYSTEMIC' named entity 'INDUCTION' named entity 'PTEN' named entity 'SUGGEST' named entity 'REDUCE' named entity 'CIA' named entity 'RECENTLY' named entity 'STAT3 ACTIVATION' named entity 'MAY BE A' named entity 'THERAPEUTIC' named entity 'RECIPROCAL' named entity 'OVEREXPRESSION' named entity 'DEMONSTRATED' named entity 'SIGNIFICANT' covid:arg/131e6a035170ed5bd2dba6bec02649e9508a0c55 named entity 'phosphatase' named entity 'therapeutic'

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