About: Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function

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About: Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function
Creator	Douglas, Trevor Harmsen, Ann Rynda-Apple, Agnieszka Young, Mark Calverley, Matthew Dobrinen, Erin Johnson, Ben Pallister, Kyler Read, Amanda Voyich, Jovanka Harmsen, Allen Richert, Laura Mcalpine, Mark Wiley, James
Source	Elsevier; Medline; PMC
abstract	The importance of the priming of the lung environment by past infections is being increasingly recognized. Exposure to any given antigen can either improve or worsen the outcome of subsequent lung infections, depending on the immunological history of the host. Thus, an ability to impart transient alterations in the lung environment in anticipation of future insult could provide an important novel therapy for emerging infectious diseases. In this study, we show that nasal administration of virus-like particles (VLPs) before, or immediately after, lethal challenge with methicillin-resistant Staphylococcus aureus (MRSA) of mice i) ensures complete recovery from lung infection and near absolute clearance of bacteria within 12 hours of challenge, ii) reduces host response-induced lung tissue damage, iii) promotes recruitment and efficient bacterial clearance by neutrophils and CD11c(+) cells, and iv) protects macrophages from MRSA-induced necrosis. VLP-mediated protection against MRSA relied on innate immunity. Complete recovery occurred in VLP-dosed mice with severe combined immunodeficiency, but not in wild-type mice depleted of either Ly6G(+) or CD11c(+) cells. Early IL-13 production associated with VLP-induced CD11c(+) cells was essential for VLP-induced protection. These results indicate that VLP-induced alteration of the lung environment protects the host from lethal MRSA pneumonia by enhancing phagocyte recruitment and killing and by reducing inflammation-induced tissue damage via IL-13–dependent mechanisms.
has issue date	2012-07-01(xsd:dateTime)
bibo:doi	10.1016/j.ajpath.2012.03.018
bibo:pmid	22642909
has license	hybrid-oa
sha1sum (hex)	131dcaa1dc8f9d68a5c65799e9eebbc1827c54a2
schema:url	https://doi.org/10.1016/j.ajpath.2012.03.018
resource representing a document's title	Virus-Like Particle-Induced Protection Against MRSA Pneumonia Is Dependent on IL-13 and Enhancement of Phagocyte Function
has PubMed Central identifier	PMC3388150
has PubMed identifier	22642909
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:131dcaa1dc8f9d68a5c65799e9eebbc1827c54a2#body_text
is schema:about of	named entity 'efficient' named entity 'IL-13' named entity 'severe combined immunodeficiency' named entity 'alterations' named entity 'reduces' named entity 'cells' named entity 'macrophages' named entity 'environment' named entity 'Function' named entity 'Pneumonia' covid:arg/131dcaa1dc8f9d68a5c65799e9eebbc1827c54a2 named entity 'Exposure' named entity 'CD11c' named entity 'environment' named entity 'host' named entity 'Thus' named entity 'damage' named entity 'lung infections' named entity 'lung' named entity 'insult' named entity 'neutrophils' named entity 'lethal' named entity 'study' named entity 'Dependent' named entity 'emerging infectious diseases' named entity 'CD11c' named entity 'host response' named entity 'lung infection' named entity 'virus-like particles' named entity 'CD11c' named entity 'inflammation' named entity 'tissue damage' named entity 'lung' named entity 'VLP' named entity 'lung infections' named entity 'Immunopathology' named entity 'Phagocyte' named entity 'Pneumonia' named entity 'FACS' named entity 'polymorphonuclear cells' named entity 'MRSA' named entity 'cellular damage' named entity 'immunodeficiency' named entity 'Norwalk virus' named entity 'hemocytometer' named entity 'BALF' named entity 'MCP-1' named entity 'opsonized' named entity 'pneumonia' named entity 'steady-state' named entity 'MRSA' named entity 'inflammation' named entity 'KO mice' named entity 'CD11c' named entity 'pneumonia' named entity 'IL-13' named entity 'PBS' named entity 'neutrophils' named entity 'MHCII' named entity 'CD11c' named entity 'infection' named entity 'DCs' named entity 'MRSA' named entity 'Tarrytown' named entity 'phenotype' named entity 'IgG1 isotype' named entity 'hybridoma' named entity 'infection'

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