About: HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells
Creator	Gougeon, M-L Melki, M-T Saïdi, H
Source	PMC
abstract	Dendritic cells (DCs) initiate immune responses by transporting antigens and migrating to lymphoid tissues to initiate T-cell responses. DCs are located in the mucosal surfaces that are involved in human immunodeficiency virus (HIV) transmission and they are probably among the earliest targets of HIV-1 infection. DCs have an important role in viral transmission and dissemination, and HIV-1 has evolved different strategies to evade DC antiviral activity. High mobility group box 1 (HMGB1) is a DNA-binding nuclear protein that can act as an alarmin, a danger signal to alert the innate immune system for the initiation of host defense. It is the prototypic damage-associated molecular pattern molecule, and it can be secreted by innate cells, including DCs and natural killer (NK) cells. The fate of DCs is dependent on a cognate interaction with NK cells, which involves HMGB1 expressed at NK–DC synapse. HMGB1 is essential for DC maturation, migration to lymphoid tissues and functional type-1 polarization of naïve T cells. This review highlights the latest advances in our understanding of the impact of HIV on the interactions between HMGB1 and DCs, focusing on the mechanisms of HMGB1-dependent viral dissemination and persistence in DCs, and discussing the consequences on antiviral innate immunity, immune activation and HIV pathogenesis.
has issue date	2011-10-28(xsd:dateTime)
bibo:doi	10.1038/cdd.2011.134
bibo:pmid	22033335
has license	no-cc
sha1sum (hex)	130a78592d496162b6584f9ed9b9ea3791a61ee7
schema:url	https://doi.org/10.1038/cdd.2011.134
resource representing a document's title	HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells
has PubMed Central identifier	PMC3252828
has PubMed identifier	22033335
schema:publication	Cell Death Differ
resource representing a document's body	covid:130a78592d496162b6584f9ed9b9ea3791a61ee7#body_text
is schema:about of	named entity 'DCs' named entity 'HIV-1 infection' named entity 'DCs' named entity 'DCs' named entity 'tissues' named entity 'initiation' named entity 'initiate' named entity 'transporting' named entity 'DCs' named entity 'pathogenesis' named entity 'ALERT' named entity 'IMMUNE ACTIVATION' named entity 'activity' named entity 'host defense' named entity 'immune' named entity 'focusing' named entity 'HMGB1' named entity 'activation' named entity 'antiviral' named entity 'Dendritic cells (DCs)' named entity 'DCs' named entity 'viral transmission' named entity 'protein' named entity 'group' named entity 'dendritic cells' named entity 'DCs' named entity 'HMGB1' named entity 'innate immune' named entity 'HMGB1' named entity 'HMGB1' named entity 'innate immunity' named entity 'DNA-binding' named entity 'DCs' named entity 'antigens' named entity 'DCs' named entity 'HIV' named entity 'nuclear protein' named entity 'binding site' named entity 'DNA binding domain' named entity 'PAMPs' named entity 'CD4 T cells' named entity 'TNF-a' named entity 'macrophages' named entity 'HMGB1' named entity 'HIV' named entity 'DCs' named entity 'regulation of transcription' named entity 'DCs' named entity 'HLA' named entity 'syngeneic' named entity 'DCs' named entity 'IL-10' named entity 'viral latency' named entity 'HIV-1' named entity 'NK cells' named entity 'HIV' named entity 'adaptive response' named entity 'NK cells' named entity 'living cells' named entity 'DCs' named entity 'leukemia cells' named entity 'cross talk' named entity 'reverse perspective' named entity 'ligand' named entity 'infection' named entity 'upregulate' named entity 'PAMPs' named entity 'minor groove' named entity 'DCs' named entity 'LPS' named entity 'cross talk' named entity 'cross talk' named entity 'chromatin' named entity 'DCs' named entity 'NK cells' named entity 'HMGB1' named entity 'HMGB1' named entity 'DCs' named entity 'oxidized'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software