About: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels

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About: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels
Creator	Li, Hui Zhang, Cong Cao, Chang-Yu Li, Jin-Long Sun, Yan-Chun Xu, Jing-Xiu Zhu, Shi-Yong
Source	PMC
abstract	To determine dietary selenium (Se) status regulates the transcriptions of selenoproteome and activities of selenoenzymes in chicken kidney, 1-day-old chickens received low Se (0.028 mg Se per kg of diet) or super-nutritional Se (3.0 or 5.0 mg Se per kg of diet) in their diets for 8 weeks. It was observed that dietary low or super-nutritional Se did not make renal appearance pathological changes in chicken. Low Se significantly reduced total antioxidant capability (T-AOC), glutathione (GSH) content, but malondialdehyde (MDA) content in the kidney increased and decreased glutathione peroxidase (Gpx) and thioredoxin reductase (TrxR) activity with changes in their mRNA levels. Super-nutritional Se (3.0 mg/kg) increased T-AOC and GSH contents then made them reduce, but it reduced MDA content significantly, elevated then reduced Gpx activity, and decreased TrxR activity with changes in their mRNA levels. Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS. At super-nutritional Se, most selenoproteins were upregulated in chicken kidney, but Sepp2 and Sep15 was only upregulated in Se excess (5.0 mg/kg) bird. These results indicated that dietary Se status stabilizes normal renal physiology function via regulation of the selenoprotemic transcriptions and selenoenzyme activities in avian. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12011-015-0470-9) contains supplementary material, which is available to authorized users.
has issue date	2015-08-19(xsd:dateTime)
bibo:doi	10.1007/s12011-015-0470-9
bibo:pmid	26282526
has license	no-cc
sha1sum (hex)	12deae51a8a41491b3f02a6ac659c06c8645064c
schema:url	https://doi.org/10.1007/s12011-015-0470-9
resource representing a document's title	Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels
has PubMed Central identifier	PMC7091239
has PubMed identifier	26282526
schema:publication	Biol Trace Elem Res
resource representing a document's body	covid:12deae51a8a41491b3f02a6ac659c06c8645064c#body_text
is schema:about of	named entity 'upregulated' named entity 'Dietary' named entity 'APPEARANCE' named entity 'GSH' named entity 'AOC' named entity 'KIDNEY' named entity 'TOTAL' named entity 'AVIAN' named entity 'FUNCTION' covid:arg/12deae51a8a41491b3f02a6ac659c06c8645064c named entity 'activity' named entity 'reduce' named entity 'activity' named entity 'regulation' named entity 'thioredoxin reductase' named entity 'renal' named entity 'reduced' named entity 'weeks' named entity 'bird' named entity 'GSH' named entity 'mRNA' named entity 'mRNA' named entity 'stabilizes' named entity 'antioxidant' named entity 'malondialdehyde' named entity 'glutathione peroxidase' named entity 'malondialdehyde' named entity 'selenoproteins' named entity 'SEPSECS' named entity 'mRNA' named entity 'kidney' named entity 'function' named entity 'activity' named entity 'intracellular' named entity 'ribosomal protein' named entity 'selenoproteins' named entity 'mRNAs' named entity 'selenoproteins' named entity 'malondialdehyde' named entity 'antioxidant' named entity 'downregulated' named entity 'high levels' named entity 'SEPSECS' named entity 'tRNA' named entity 'Sepp1' named entity 'GSSG' named entity 'substrate' named entity 'prokaryotes' named entity 'oxidative stress' named entity 'gene' named entity 'selenoprotein' named entity 'stop signal' named entity 'selenocysteine' named entity 'oxidative damage' named entity 'selenoprotein' named entity 'redox status' named entity 'mitochondrial' named entity 'Gpx1' named entity 'microRNAs' named entity 'Selm' named entity 'mRNAs' named entity 'oxidative stress' named entity 'kidney' named entity 'microscope' named entity 'enzyme' named entity 'formaldehyde' named entity 'qPCR' named entity 'toxicity' named entity 'selenoprotein' named entity 'amino acid' named entity 'selenoprotein' named entity '5.0' named entity 'Bioengineering' named entity 'metabolism' named entity 'kidney'

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