About: Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State

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About: Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State
Creator	Cho, Won-Kyung Lee, Jong-Soo Kim, Chul-Joong Weeratunga, Prasanna Lee, Byeong-Hoon Park, Jun-Seol Ma, Jin
Source	Medline; PMC
abstract	Epimedium koreanum Nakai has been extensively used in traditional Korean and Chinese medicine to treat a variety of diseases. Despite the plant’s known immune modulatory potential and chemical make-up, scientific information on its antiviral properties and mode of action have not been completely investigated. In this study, the broad antiviral spectrum and mode of action of an aqueous extract from Epimedium koreanum Nakai was evaluated in vitro, and moreover, the protective effect against divergent influenza A subtypes was determined in BALB/c mice. An effective dose of Epimedium koreanum Nakaimarkedly reduced the replication of Influenza A Virus (PR8), Vesicular Stomatitis Virus (VSV), Herpes Simplex Virus (HSV) and Newcastle Disease Virus (NDV) in RAW264.7 and HEK293T cells. Mechanically, we found that an aqueous extract from Epimedium koreanum Nakai induced the secretion of type I IFN and pro-inflammatory cytokines and the subsequent stimulation of the antiviral state in cells. Among various components present in the extract, quercetin was confirmed to have striking antiviral properties. The oral administration of Epimedium koreanum Nakai exhibited preventive effects on BALB/c mice against lethal doses of highly pathogenic influenza A subtypes (H1N1, H5N2, H7N3 and H9N2). Therefore, an extract of Epimedium koreanum Nakai and its components play roles as immunomodulators in the innate immune response, and may be potential candidates for prophylactic or therapeutic treatments against diverse viruses in animal and humans.
has issue date	2015-01-20(xsd:dateTime)
bibo:doi	10.3390/v7010352
bibo:pmid	25609307
has license	cc-by
sha1sum (hex)	12c2a6ee1e3e7cf0f915e5c5454627b7e1ed9db3
schema:url	https://doi.org/10.3390/v7010352
resource representing a document's title	Epimedium koreanum Nakai Displays Broad Spectrum of Antiviral Activity in Vitro and in Vivo by Inducing Cellular Antiviral State
has PubMed Central identifier	PMC4306843
has PubMed identifier	25609307
schema:publication	Viruses
resource representing a document's body	covid:12c2a6ee1e3e7cf0f915e5c5454627b7e1ed9db3#body_text
is schema:about of	covid:arg/12c2a6ee1e3e7cf0f915e5c5454627b7e1ed9db3 named entity 'HSV' named entity 'aqueous' named entity 'Epimedium' named entity 'NDV' named entity 'Newcastle Disease Virus' named entity 'Epimedium' named entity 'VSV' named entity 'Epimedium' named entity 'mice' named entity 'antiviral' named entity 'Antiviral' named entity 'Epimedium' named entity 'Antiviral Activity' named entity 'Epimedium' named entity 'anti-bacterial' named entity 'lung' named entity 'treatment group' named entity 'homogenate' named entity 'supernatant' named entity 'influenza virus' named entity 'IFN' named entity 'serially diluted' named entity 'contaminant' named entity 'reverse transcriptase' named entity 'HEK293T' named entity 'Epimedium' named entity 'SDS-PAGE' named entity 'Epimedium' named entity 'MDCK' named entity 'orally administered' named entity 'ISGs' named entity 'Epimedium' named entity 'Epimedium' named entity 'secretion' named entity 'TBK1' named entity 'H5N2' named entity 'lung' named entity 'antimycotics' named entity 'homogenized' named entity 'JAK-STAT' named entity 'actin' named entity 'aqueous' named entity 'PRRs' named entity 'phosphorylation' named entity 'cytokines' named entity 'Epimedium' named entity '5.0' named entity 'quercetin' named entity 'Student's t-test' named entity 'inocula' named entity 'aqueous' named entity 'Bioneer' named entity 'Tween 20' named entity 'vaccination' named entity 'antiviral' named entity 'antiviral agent' named entity 'CO2' named entity 'Epimedium' named entity '3.5' named entity 'quercetin' named entity 'Epimedium' named entity 'HEK293T' named entity 'DMEM' named entity 'transcription' named entity 'HEK293T' named entity 'virus infection' named entity 'IL-6' named entity 'Missouri' named entity 'aqueous' named entity 'trypan blue' named entity 'pro-inflammatory cytokine' named entity 'lungs' named entity 'pro-inflammatory cytokines' named entity 'pro-inflammatory cytokines'

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