About: Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks
Creator	Uzoma, Ijeoma Zhu, Heng
topic	covid:12b90b3a09c938535dbf8db6af029cba7994e2cc#this
Source	Elsevier; Medline; PMC
abstract	A major focus of systems biology is to characterize interactions between cellular components, in order to develop an accurate picture of the intricate networks within biological systems. Over the past decade, protein microarrays have greatly contributed to advances in proteomics and are becoming an important platform for systems biology. Protein microarrays are highly flexible, ranging from large-scale proteome microarrays to smaller customizable microarrays, making the technology amenable for detection of a broad spectrum of biochemical properties of proteins. In this article, we will focus on the numerous studies that have utilized protein microarrays to reconstruct biological networks including protein–DNA interactions, posttranslational protein modifications (PTMs), lectin–glycan recognition, pathogen–host interactions and hierarchical signaling cascades. The diversity in applications allows for integration of interaction data from numerous molecular classes and cellular states, providing insight into the structure of complex biological systems. We will also discuss emerging applications and future directions of protein microarray technology in the global frontier.
has issue date	2013-01-17(xsd:dateTime)
bibo:doi	10.1016/j.gpb.2012.12.005
bibo:pmid	23395178
has license	cc-by-nc-sa
sha1sum (hex)	12b90b3a09c938535dbf8db6af029cba7994e2cc
schema:url	https://doi.org/10.1016/j.gpb.2012.12.005
resource representing a document's title	Interactome Mapping: Using Protein Microarray Technology to Reconstruct Diverse Protein Networks
has PubMed Central identifier	PMC3968920
has PubMed identifier	23395178
schema:publication	Genomics Proteomics Bioinformatics
resource representing a document's body	covid:12b90b3a09c938535dbf8db6af029cba7994e2cc#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/12b90b3a09c938535dbf8db6af029cba7994e2cc
is schema:about of	named entity 'DIVERSE' named entity 'A MAJOR' named entity 'CLASSES' named entity 'RECOGNITION' named entity 'TO CHARACTERIZE' named entity 'HIGHLY' named entity 'ARTICLE' named entity 'MICROARRAYS' named entity 'APPLICATIONS' named entity 'PLATFORM' named entity 'GLOBAL' named entity 'SYSTEMS BIOLOGY' named entity 'ACCURATE' named entity 'SCALE' named entity 'GREATLY' named entity 'FOCUS' named entity 'PICTURE' named entity 'DETECTION' named entity 'PROTEIN MICROARRAYS' named entity 'INTERACTIONS' named entity 'FLEXIBLE' named entity 'STUDIES' named entity 'RECONSTRUCT' named entity 'INCLUDING' named entity 'BIOLOGICAL' named entity 'microarrays' named entity 'applications' named entity 'reconstruct' named entity 'applications' named entity 'microarrays' named entity 'Protein' named entity 'RECONSTRUCT' named entity 'PROTEIN MICROARRAY' named entity 'PROTEIN MICROARRAY' named entity 'DECADE' named entity 'AMENABLE' named entity 'PROTEIN ' named entity 'INTERACTOME' named entity 'SIGNALING CASCADES' named entity 'BIOLOGICAL NETWORKS' named entity 'TECHNOLOGY' named entity 'PROVIDING' named entity 'ORDER' named entity 'BIOCHEMICAL' named entity 'PROTEIN MODIFICATIONS' named entity 'SMALLER' named entity 'USING' named entity 'MAPPING' named entity 'MICROARRAY TECHNOLOGY' named entity 'NETWORKS' named entity 'STATES' named entity 'PATHOGEN' named entity 'PROTEOMICS' named entity 'PROTEINS' named entity 'LARGE' named entity 'MOLECULAR' named entity 'HOST' named entity 'CELLULAR' named entity 'COMPLEX' named entity 'NUMEROUS' named entity 'PROTEOME' named entity 'NETWORKS' named entity 'LECTIN' named entity 'GLYCAN' named entity 'INTERACTION DATA' named entity 'DIVERSITY' named entity 'PROPERTIES' named entity 'ALLOWS' named entity 'MICROARRAY TECHNOLOGY' named entity 'FUTURE' named entity 'IMPORTANT' named entity 'DIRECTIONS' named entity 'INSIGHT' named entity 'PROTEIN-DNA INTERACTIONS' named entity 'STRUCTURE' named entity 'HAVE' named entity 'PAST' named entity 'INTEGRATION'

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