About: Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients

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About: Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients
Creator	Chen, Bing Zhang, Jun Alter, Galit Ryan, Edward Charles, Richelle Cai, Yongfei Caradonna, Timothy Feldman, Jared Gilboa, Tal Hauser, Blake Norman, Maia Schmidt, Aaron Walt, David Cohen, Limor Maley, Adam Ogata, Alana
Source	MedRxiv; Medline
abstract	The COVID-19 pandemic continues to infect millions of people worldwide. In order to curb its spread and reduce morbidity and mortality, it is essential to develop sensitive and quantitative methods that identify infected individuals and enable accurate population-wide screening of both past and present infection. Here we show that Single Molecule Array assays detect seroconversion in COVID-19 patients as soon as one day after symptom onset using less than a microliter of blood. This multiplexed assay format allows us to quantitate IgG, IgM and IgA immunoglobulins against four SARS-CoV-2 targets, thereby interrogating 12 antibody isotype-viral protein interactions to give a high resolution profile of the immune response. Using a cohort of samples collected prior to the outbreak as well as samples collected during the pandemic, we demonstrate a sensitivity of 86% and a specificity of 100% during the first week of infection, and 100% sensitivity and specificity thereafter. This assay should become the gold standard for COVID19 serological profiling and will be a valuable tool for answering important questions about the heterogeneity of clinical presentation seen in the ongoing pandemic.
has issue date	2020-05-02(xsd:dateTime)
bibo:doi	10.1101/2020.04.28.20083691
bibo:pmid	32511657
has license	medrxiv
sha1sum (hex)	122c9e7215ad5b79425da2ac3972ac57259949ae
schema:url	https://doi.org/10.1101/2020.04.28.20083691
resource representing a document's title	Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients
has PubMed identifier	32511657
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:122c9e7215ad5b79425da2ac3972ac57259949ae#body_text
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