About: Age-related Changes in Rat Muscle Glycogen Synthase Activity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Age-related Changes in Rat Muscle Glycogen Synthase Activity
Creator	Azhar, Salman Chang, Helen Dall'aglio, Elisabetta Reaven, Gerald
Source	PMC
abstract	This study was designed to evaluate effects of aging on glycogen synthase activity in rat skeletal muscle. Total enzyme activity was shown to be significantly, (p < .001) lower in tensor fascia latae, biceps femoris, and soleus muscle obtained from 24-month-old compared with 2-month-old rats. Similarly, values for the active form of enzyme were significantly lower, (p < .001) in all three muscle types of 24-month-old compared with 2-month-old rats. This age-related decline in glycogen synthase activity was not due to a reduction in the affinity of the enzyme for its activator (glucose-6-phosphate) and was independent of the concentration of substrate (UDP-glucose) in the assay system. Because similar age-related changes were seen when enzyme activity was expressed per milligram of muscle protein or per gram of muscle tissue, the fall in enzyme activity was not a simple function of an age-related decline in muscle mass. Glycogen levels also were reduced significantly in tensor fascia latae, biceps femoris, and soleus of 24-monthold rats compared with 2-month-old rats, p < .001. These results document an age-related change in a key enzyme regulating glycogen metabolism in muscle.
has issue date	1987-03-01(xsd:dateTime)
bibo:doi	10.1093/geronj/42.2.168
bibo:pmid	3102591
has license	no-cc
sha1sum (hex)	120daf551e6187f5b06a5505dce038736d83e1fc
schema:url	https://doi.org/10.1093/geronj/42.2.168
resource representing a document's title	Age-related Changes in Rat Muscle Glycogen Synthase Activity
has PubMed Central identifier	PMC7108525
has PubMed identifier	3102591
schema:publication	J Gerontol
resource representing a document's body	covid:120daf551e6187f5b06a5505dce038736d83e1fc#body_text
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