About: In-depth virological assessment of kidney transplant recipients with COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In-depth virological assessment of kidney transplant recipients with COVID-19
Creator	Panaget, Baptiste Baldacini1, Clement Bassand1, Xavier Bedo1, Dimitri Benotmane1, Ilies Bozman1, Dogan-Firat Braun1, Laura Caillard1, Sophie Chiesa1, Margaux Cognard1, Noëlle Delagreverie2, Héloïse Fafi-Kremer2, Samira Gallais2, Floriane Gontard2, Louise Heibel1, Francoise Marx1, David Moulin1, Bruno Olagne1, Jerome Perrin1, Peggy Sagnard1, Mylene Solis2, Morgane Vargas1, Gabriela Velay2, Aurélie Wendling2, Marie-Josée
source	MedRxiv
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing coronavirus disease 2019 (COVID-19) and significant mortality. However, data on viral loads and antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal and plasma viral loads via RT-PCR and SARS-CoV-2 serology via ELISA and study their association with severe forms of COVID-19 and death in kidney transplant recipients. In this study we examined hospitalized kidney transplant recipients with non-severe (n = 21) and severe (n =19) COVID-19. SARS-CoV-2 nasopharyngeal and plasma viral load and serological response were evaluated based on outcomes and disease severity. Ten recipients (25%) displayed persistent viral shedding 30 days after symptom onset. The SARS-CoV-2 viral load of the upper respiratory tract was not associated with severe COVID-19, whereas the plasma viral load was associated with COVID-19 severity (p=0.0087) and mortality (p=0.024). All patients harbored antibodies the second week after symptom onset that persisted for two months. We conclude that plasma viral load is associated with COVID-19 morbidity and mortality, whereas nasopharyngeal viral load is not. SARS-CoV-2 shedding is prolonged in kidney transplant recipients and the humoral response to SARS-CoV-2 does not show significant impairment in this series of transplant recipients.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1101/2020.06.17.20132076
has license	medrxiv
sha1sum (hex)	11e16ac0882737ee271a39741362852417ba9784
schema:url	https://doi.org/10.1101/2020.06.17.20132076
resource representing a document's title	In-depth virological assessment of kidney transplant recipients with COVID-19
resource representing a document's body	covid:11e16ac0882737ee271a39741362852417ba9784#body_text
is schema:about of	named entity 'virological' named entity 'COVID-19' named entity 'kidney transplant' named entity 'symptom' named entity 'viral load' named entity 'viral load' named entity 'IQR' named entity 'follow-up' named entity 'immunocompromised' named entity 'immunocompromised' named entity 'RT-PCR' named entity 'peer review' named entity 'nasopharyngeal' named entity 'virus' named entity 'Survival plots' named entity 'C-reactive protein' named entity 'symptom' named entity 'respiratory tract' named entity 'ROC' named entity 'IgG antibody' named entity 'viral load' named entity 'body mass index' named entity 'SARS-CoV-2' named entity '50%' named entity 'peer review' named entity 'RT-PCR' named entity 'medRxiv' named entity 'viruses' named entity 'interquartile' named entity 'sample size' named entity 'viral shedding' named entity 'viral load' named entity 'peer review' named entity 'upper respiratory' named entity 'p=0.05' named entity 'BMI' named entity 'viral load' named entity 'log10' named entity 'viral load' named entity 'general population' named entity 'SARS-CoV-2' named entity 'medRxiv' named entity 'medRxiv' named entity 'peer review' named entity 'mTOR inhibitors' named entity 'peer review' named entity 'ROC' named entity 'medRxiv' named entity 'log-rank test' named entity 'ICU' named entity 'correlation coefficient' named entity 'SARS-CoV-2' named entity 'viral load' named entity 'viral load' named entity 'immunocompromised' named entity 'Kaplan-Meier' named entity 'serology' named entity 'clinical outcomes' named entity 'IgG antibodies' named entity 'medRxiv' named entity 'medRxiv' named entity 'RT-PCR'

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