About: Genetic analysis of the novel SARS-CoV-2 host receptor TMPRSS2 in different populations

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About: Genetic analysis of the novel SARS-CoV-2 host receptor TMPRSS2 in different populations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic analysis of the novel SARS-CoV-2 host receptor TMPRSS2 in different populations
Creator	Andolfo, Immacolata Capasso, Mario Iolascon, Achille Lasorsa, Vito Mario, Capasso Russo, Roberta
Source	BioRxiv
abstract	The infection coronavirus disease 2019 (COVID-19) is caused by a virus classified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At cellular level, virus infection initiates with binding of viral particles to the host surface cellular receptor angiotensin converting enzyme 2 (ACE2). SARS-CoV-2 engages ACE2 as the entry receptor and employs the cellular serine protease 2 (TMPRSS2) for S protein priming. TMPRSS2 activity is essential for viral spread and pathogenesis in the infected host. Understanding how TMPRSS2 protein expression in the lung varies in the population could reveal important insights into differential susceptibility to influenza and coronavirus infections. Here, we systematically analyzed coding-region variants in TMPRSS2 and the eQTL variants, which may affect the gene expression, to compare the genomic characteristics of TMPRSS2 among different populations. Our findings suggest that the lung-specific eQTL variants may confer different susceptibility or response to SARS-CoV-2 infection from different populations under the similar conditions. In particular, we found that the eQTL variant rs35074065 is associated with high expression of TMPRSS2 but with a low expression of the interferon (IFN)-α/β-inducible gene, MX1, splicing isoform. Thus, these subjects could account for a more susceptibility either to viral infection or to a decrease in cellular antiviral response.
has issue date	2020-04-24(xsd:dateTime)
bibo:doi	10.1101/2020.04.23.057190
has license	biorxiv
sha1sum (hex)	11a27e81a2b607cad6243f6231e7454642b97699
schema:url	https://doi.org/10.1101/2020.04.23.057190
resource representing a document's title	Genetic analysis of the novel SARS-CoV-2 host receptor TMPRSS2 in different populations
schema:publication	bioRxiv
resource representing a document's body	covid:11a27e81a2b607cad6243f6231e7454642b97699#body_text
is schema:about of	named entity 'TMPRSS2' named entity 'viral spread' named entity 'host' named entity 'infection' named entity 'receptor' named entity 'subjects' named entity 'serine protease' named entity 'influenza' named entity 'SARS-CoV-2' named entity 'coronavirus disease 2019' named entity 'isoform' named entity 'pathogenesis' named entity 'reveal' named entity 'lung' named entity 'infections' named entity 'level' named entity 'enzyme' named entity 'angiotensin' named entity 'Genetic analysis' named entity 'MX1' named entity 'coronavirus infections' named entity 'SARS-CoV-2' named entity 'IFN' named entity 'protein expression' named entity 'cellular level' named entity 'TMPRSS2' named entity 'virus' named entity 'infection' named entity 'SARS-CoV-2' named entity 'protein' named entity 'differential susceptibility' named entity 'antiviral' named entity 'gene expression' named entity 'isoform' named entity 'SARS-CoV-2' named entity 'lung' named entity 'viral infection' named entity 'SARS-CoV-2' named entity 'cellular' named entity 'TMPRSS2' named entity 'homeostasis' named entity 'gene' named entity 'eQTL' named entity 'sample size' named entity 'TMPRSS2' named entity 'differential susceptibility' named entity 'H7N9' named entity 'TMPRSS2' named entity 'SARS-CoV-2' named entity 'influenza' named entity 'bronchus' named entity 'testis' named entity 'MX1' named entity 'type 1' named entity 'TMPRSS2' named entity 'TMPRSS2' named entity 'infection' named entity 'eQTLs' named entity 'TMPRSS2' named entity 'single nucleotide polymorphisms' named entity 'respiratory tract' named entity 'TMPRSS2' named entity 'eQTL' named entity 'TMPRSS2' named entity 'acute respiratory distress syndrome' named entity 'eQTL' named entity 'protein expression' named entity 'protein' named entity 'TMPRSS2' named entity 'epithelial cells' named entity 'eQTL' named entity 'gene' named entity 'TMPRSS2' named entity 'coronaviruses' named entity 'mRNA expression' named entity 'Wuhan' named entity 'interferon' named entity 'MX1' named entity 'respiratory tract'

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