About: Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus

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About: Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus
Creator	Chang, William Alliston, Gerald Aravapalli, Kevin Groutas, Hua, Kyeong-Ok Kim, Duy Lushington, Yunjeong Mandadapu, Pathum Prior, Roxanne Sivakoteswara, Rao Uy, Sridhar Weerawarna, Allan
Source	Elsevier; Medline; PMC
abstract	The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective concentration) of the macrocyclic inhibitor toward enterovirus 3C protease (CVB3 Nancy strain), and coronavirus (SARS-CoV) and norovirus 3C-like proteases, was determined to be 1.8, 15.5 and 5.1 μM, respectively.
has issue date	2013-07-01(xsd:dateTime)
bibo:doi	10.1016/j.bmcl.2013.05.021
bibo:pmid	23727045
has license	bronze-oa
sha1sum (hex)	119d76e13a16297a7a15446e2d75fe72c9153230
schema:url	https://doi.org/10.1016/j.bmcl.2013.05.021
resource representing a document's title	Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus
has PubMed Central identifier	PMC3750990
has PubMed identifier	23727045
schema:publication	Bioorganic & Medicinal Chemistry Letters
resource representing a document's body	covid:119d76e13a16297a7a15446e2d75fe72c9153230#body_text
is schema:about of	named entity 'norovirus' named entity 'Macrocyclic' named entity 'coronavirus' named entity 'INHIBITORS' named entity 'NOROVIRUS' named entity 'LIKE' named entity 'CORONAVIRUS' named entity 'PROTEASES' named entity 'PICORNAVIRUS' named entity 'Cbz' named entity 'arginine' named entity 'cationic' named entity 'proteases' named entity 'coronavirus' named entity 'proteases' named entity 'THF' named entity 'alkyl azide' named entity 'coronavirus' named entity 'protease' named entity 'SARS-CoV' named entity 'proteolytic processing' named entity 'aqueous' named entity 'LiOH' named entity 'alcohol' named entity 'N-terminal' named entity 'PyMol' named entity 'macrocyclic' named entity 'protein data bank' named entity 'chymotrypsin-like' named entity 'conformation' named entity 'protective group' named entity 'norovirus' named entity 'Cbz' named entity 'virus replication' named entity 'Cys' named entity 'substrate specificity' named entity 'effective concentration' named entity 'receptor' named entity '3C protease' named entity 'HCl' named entity 'aldehyde' named entity 'Glu' named entity 'ligands' named entity 'aspartate' named entity 'positive sense' named entity 'Cyclization' named entity 'macrocyclic' named entity 'ester' named entity 'Pymol' named entity 'macrocyclization' named entity 'macrocyclic' named entity 'receptor binding' named entity '3CLpro' named entity 'inhibitory activity' named entity 'picornavirus' named entity 'binding site' named entity 'Boc protecting group' named entity 'HOBt' named entity 'picornavirus' named entity 'coronavirus' named entity 'SARS-CoV' named entity 'proteolytic processing' named entity 'isobutyl group' named entity 'dioxane' named entity 'Cys' named entity 'protonating' named entity 'polyprotein' named entity 'active site' named entity 'viral pathogens' named entity 'genetic diversity'

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