About: Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV

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About: Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV
Creator	Thiel, Volker Pichlmair, Andreas Ziebuhr, John Wang, Anqi Scaturro, Pietro Protzer, Ulrike Mann, Matthias Jores, Jörg Ehmann, Rosina Wölfel, Roman Piras, Antonio Urban, Christian Stukalov, Alexey Bergant, Valter Enghleitner, Thomas Girault, Virginie Grass, Vincent Haas, Darya Hamad, Sabri Hansen, Fynn Huang, Yiqi Karayel, Ozge Kuster, Bernhard Lavacca, Teresa Oubraham, Lila Rad, Roland Reinecke, Maria Tanzer, Maria
Source	BioRxiv
abstract	The sudden global emergence of SARS-CoV-2 urgently requires an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several omics studies have extended our knowledge of COVID-19 pathophysiology, including some focused on proteomic aspects1–3. To understand how SARS-CoV-2 and related coronaviruses manipulate the host we here characterized interactome, proteome and signaling processes in a systems-wide manner. This identified connections between the corresponding cellular events, revealed functional effects of the individual viral proteins and put these findings into the context of host signaling pathways. We investigated the closely related SARS-CoV-2 and SARS-CoV viruses as well as the influence of SARS-CoV-2 on transcriptome, proteome, ubiquitinome and phosphoproteome of a lung-derived human cell line. Projecting these data onto the global network of cellular interactions revealed relationships between the perturbations taking place upon SARS-CoV-2 infection at different layers and identified unique and common molecular mechanisms of SARS coronaviruses. The results highlight the functionality of individual proteins as well as vulnerability hotspots of SARS-CoV-2, which we targeted with clinically approved drugs. We exemplify this by identification of kinase inhibitors as well as MMPase inhibitors with significant antiviral effects against SARS-CoV-2.
has issue date	2020-06-17(xsd:dateTime)
bibo:doi	10.1101/2020.06.17.156455
has license	biorxiv
sha1sum (hex)	113725e4459df43466b2a8084f8fffd3bbb2245f
schema:url	https://doi.org/10.1101/2020.06.17.156455
resource representing a document's title	Multi-level proteomics reveals host-perturbation strategies of SARS-CoV-2 and SARS-CoV
schema:publication	bioRxiv
resource representing a document's body	covid:113725e4459df43466b2a8084f8fffd3bbb2245f#body_text
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