About: Clinical features and sexual transmission potential of SARS-CoV-2 infected female patients: a descriptive study in Wuhan, China

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About: Clinical features and sexual transmission potential of SARS-CoV-2 infected female patients: a descriptive study in Wuhan, China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features and sexual transmission potential of SARS-CoV-2 infected female patients: a descriptive study in Wuhan, China
Creator	Liu, Jia Zhang, Cong Wang, Tian Miao, Xiaoping Chen, Zhe Jiang, Jingjing Cui, Pengfei Dai, Jun Chang, Jiang Wang, Sheng Ding, Ting Ma, Prof Ma, Xiangyi Rong, Yueguang Shan, Wanying Wang, Shixuan Zhang, Jinjin
Source	MedRxiv
abstract	Background: As of March 2, 2020, SARS-CoV-2 has infected more than 80174 people and caused 2915 deaths in China. This virus rapidly spreads to 56 countries worldwide. Thus, in order to effectively block its transmission, it is urgent to uncover all the possible transmission routes of SARS-CoV-2. Methods: From January 28 to February 18, 2020, 35 female patients diagnosed with COVID-19 in Tongji Hospital were included in this descriptive study. The gynecologic history, clinical characteristics, laboratory findings and chest computed tomography (CT) of all patients were recorded in detail. To examine whether there is sexual transmission through vaginal from female to her partner, we employed real-time polymerase chain reaction testing (RT-PCR) to detect SARS-CoV-2 in vaginal environment (including vaginal discharge, cervical or vaginal residual exfoliated cells) and anal swab samples, and inquired recent sexual behaviors from the patients. Findings: The age range of the 35 patients with COVID-19 was 37-88 years. Over 50% patients infected with SARS-CoV-2 had chronic diseases. We tested the vaginal environment and anal swabs from the 35 female patients with COVID-19 and found that only an anal swab sample from one patient was positive for SARS-CoV-2. All the samples from vaginal environment were negative for SARS-CoV-2. The infection rate of the patients' sexual partner was 42.9%. Additionally, two female patients admitted having sex with their partners during a possible infection incubation period, while one patient's partner was uninfected and the other patient's partner was diagnosed with COVID-19 (after the diagnosis of the female patient). Conclusion: No positive RT-PCR result was found in the vaginal environment perhaps due to the lack of ACE2 expression, which is the receptor of SARS-CoV-2, in the vagina and cervix tissues (human protein atlas). The results from this study show no evidence of transmission of SARS-CoV-2 through vaginal sex from female to her partner. However, the risk of infection of non vaginal sex and other intimate contacts during vaginal sex should not be ignored.
has issue date	2020-02-27(xsd:dateTime)
bibo:doi	10.1101/2020.02.26.20028225
has license	medrxiv
sha1sum (hex)	111b9a6e91c938696fcdb4cb128b8ae739dbe11c
schema:url	https://doi.org/10.1101/2020.02.26.20028225
resource representing a document's title	Clinical features and sexual transmission potential of SARS-CoV-2 infected female patients: a descriptive study in Wuhan, China
resource representing a document's body	covid:111b9a6e91c938696fcdb4cb128b8ae739dbe11c#body_text
is schema:about of	named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'However' named entity 'sex' named entity 'patients' named entity 'samples' named entity 'detect' named entity 'vaginal' covid:arg/111b9a6e91c938696fcdb4cb128b8ae739dbe11c named entity 'female' named entity 'environment' named entity 'caused' named entity 'The infection' named entity 'chronic diseases' named entity 'chain reaction' named entity 'gynecologic' named entity 'sexual transmission' named entity 'RT-PCR' named entity 'intimate' named entity 'Hospital' named entity 'recorded' named entity 'behaviors' named entity 'female' named entity 'female' named entity 'female' named entity 'patient' named entity 'tested' named entity 'environment' named entity 'vaginal' named entity 'infection' named entity 'SARS-CoV-2' named entity 'diagnosis' named entity 'rapidly' named entity 'study' named entity 'All' named entity 'patients' named entity 'COVID' named entity 'COVID-19' named entity 'computed tomography' named entity 'sexual partner' named entity 'COVID-19' named entity 'sexual behaviors' named entity 'infection rate' named entity 'incubation period' named entity 'SARS-CoV-2' named entity 'Clinical features' named entity 'CT scan' named entity 'incubation period' named entity 'medRxiv' named entity 'aspartate transaminase' named entity 'incubation period' named entity 'COVID-19' named entity 'COVID' named entity 'preprint' named entity 'virus' named entity 'serum sodium' named entity 'fever' named entity 'preprint' named entity 'preprint' named entity 'medRxiv' named entity 'SARS-CoV-2' named entity 'IL-2R' named entity 'peer-reviewed' named entity 'lymphocyte count' named entity 'infection' named entity 'preprint' named entity 'preprint' named entity 'SARS-CoV' named entity 'infection'

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