About: Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection

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About: Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection
Creator	Desforges, Marc Gruslin, Edith Moisan, Steve St-Pierre, Yves Talbot, Pierre
Source	Elsevier; Medline; PMC
abstract	Multiple sclerosis (MS) is an autoimmune disease associated with environmental factors, possibly including several viruses such as the coronaviruses. Indeed, murine coronavirus (MHV) infection provides a well-known experimental model for MS studies. Intracerebral infection of C57BL/6 mice with MHV-A59 revealed that viral replication was efficient and that clearance of infectious virus occurred as soon as 7 days post-infection. Using cDNA arrays, analysis of gene expression profile in the brain revealed a modulation of 80 different genes following infection, with at least 27 of these genes having previously been directly related to innate or acquired immune responses. Concordingly, an important activation of auto-reactive T cells specific to myelin basic protein was demonstrated. Altogether, these results indicate that an MHV infection of the central nervous system (CNS) leads to an important host genomic response implicating immunity-related genes and to the activation of myelin-reactive autoimmune T cells.
has issue date	2005-03-10(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2005.01.007
bibo:pmid	15833360
has license	no-cc
sha1sum (hex)	10f0e5ba15bc80507c2f42178104e211adcc2d83
schema:url	https://doi.org/10.1016/j.jneuroim.2005.01.007
resource representing a document's title	Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection
has PubMed Central identifier	PMC7112872
has PubMed identifier	15833360
schema:publication	J Neuroimmunol
resource representing a document's body	covid:10f0e5ba15bc80507c2f42178104e211adcc2d83#body_text
is schema:about of	named entity 'cDNA' named entity 'autoimmune' named entity 'auto-reactive' named entity 'infection' named entity 'central nervous system' covid:arg/10f0e5ba15bc80507c2f42178104e211adcc2d83 named entity 'ACTIVATION' named entity 'FOLLOWING' named entity 'A59' named entity 'MYELIN' named entity 'REACTIVE' named entity 'DISEASE ASSOCIATED' named entity 'CDNA ARRAYS' named entity 'MHV' named entity 'VIRAL REPLICATION' named entity 'REACTIVE' named entity 'GENOMIC' named entity 'IMPORTANT' named entity 'OCCURRED' named entity 'MURINE CORONAVIRUS' named entity 'FOLLOWING' named entity 'REVEALED' named entity 'CLEARANCE' named entity 'DIRECTLY' named entity 'USING' named entity 'SPECIFIC' named entity 'EXPERIMENTAL MODEL' named entity 'KNOWN' named entity 'ACQUIRED' named entity 'PREVIOUSLY' named entity 'MOUSE CENTRAL NERVOUS SYSTEM' named entity 'TRANSCRIPTOME PROFILE' named entity 'RESPONSE' named entity 'POSSIBLY' named entity 'T CELLS' named entity 'MURINE CORONAVIRUS' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'INCLUDING' named entity 'MYELIN BASIC PROTEIN' named entity 'PROVIDES' named entity 'CORONAVIRUSES' named entity 'DEMONSTRATED' named entity 'AUTO' named entity 'CORONAVIRUS INFECTION' named entity 'LEADS' named entity 'MODULATION' named entity 'C57BL' named entity 'MULTIPLE SCLEROSIS' named entity 'INFECTIOUS' named entity 'INFECTION' named entity 'THE BRAIN' named entity 'DIFFERENT' named entity 'ENVIRONMENTAL FACTORS' named entity 'GENES' named entity 'T CELLS' named entity 'EFFICIENT' named entity 'VIRUSES' named entity 'ACTIVATION' named entity 'INTRACEREBRAL' named entity 'HOST' named entity 'PROTEIN ' named entity 'ANALYSIS' named entity 'THESE' named entity 'POST' named entity 'AUTOIMMUNE' named entity 'ASSOCIATED WITH' named entity 'MICE' named entity 'RELATED' named entity 'IMMUNE RESPONSES' named entity 'MYELIN' named entity 'RESULTS' named entity 'VIRUS' named entity 'AUTOIMMUNE DISEASE' named entity 'SOON' named entity 'STUDIES' named entity 'GENE EXPRESSION PROFILE' named entity 'DAYS'

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