About: Evaluation of coagulation status using viscoelastic testing in Intensive Care patients with COVID-19: An observational point prevalence cohort study

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About: Evaluation of coagulation status using viscoelastic testing in Intensive Care patients with COVID-19: An observational point prevalence cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of coagulation status using viscoelastic testing in Intensive Care patients with COVID-19: An observational point prevalence cohort study
Creator	Ba, Chb, Gov, John, Ma, Mbbs, Au, Au, Benjamin Au, Richard Au, Samuel Chb, M Collett, Luke Collett@sa, Luke Gluck, Samuel Gluck@sa, Michael, Michael, Benjamin Reddi, Benjamin Reddi, M Reddi@sa, Strickland, Richard Strickland@sa, Wallace,
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Coronavirus-19 (COVID-19) is associated with a high rate of thrombosis, the pathophysiology of which is not well defined. Viscoelastic testing may identify and characterise hypercoagulable states which are not apparent using conventional coagulation assays OBJECTIVES: To undertake viscoelastic evaluation of the coagulation state in critically ill adults with COVID-19 associated respiratory failure METHODS: Single centre observational point prevalence cohort study of adults requiring respiratory support in the intensive care unit with COVID-19 associated respiratory failure. Coagulation status was evaluated using rotational thromboelastometry in conjunction with laboratory markers of coagulation. RESULTS: Six patients fulfilled inclusion criteria. Each patient had one ROTEM performed. All patients had supra-normal clot amplitude at 10 minutes (A10) and supra-normal clot firmness (MCF) measured in at least one ROTEM pathway, and 5 were supra-normal on all pathways. Minimal clot lysis was present on all analyses. Fibrinogen and d-dimer were elevated and routine markers of coagulation within normal ranges in all patients. CONCLUSION: Patients admitted to ICU with COVID-19 associated respiratory failure exhibit a hyper-coagulable state which is not appreciable on conventional tests of coagulation. Supra-normal clot firmness, minimal fibrinolysis and hyperfibrinogenaemia are key findings. Further research is required into the pathophysiology of this hypercoagulable state, as well as the harms and benefits of different anticoagulation strategies.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.1016/j.aucc.2020.07.003
bibo:pmid	32773357
has license	no-cc
sha1sum (hex)	10c35fc1999274e4b65ab30b8f6d5bb755c2908e
schema:url	https://doi.org/10.1016/j.aucc.2020.07.003
resource representing a document's title	Evaluation of coagulation status using viscoelastic testing in Intensive Care patients with COVID-19: An observational point prevalence cohort study
has PubMed Central identifier	PMC7373052
has PubMed identifier	32773357
schema:publication	Aust Crit Care
resource representing a document's body	covid:10c35fc1999274e4b65ab30b8f6d5bb755c2908e#body_text
is schema:about of	named entity 'observational' named entity 'viscoelastic' named entity 'COVID' named entity 'Evaluation' named entity 'Evaluation' named entity 'observational' named entity 'patients' named entity 'Journal' named entity 'Intensive Care' named entity 'Intensive Care' named entity 'coagulation' named entity 'point prevalence' named entity 'clot lysis' named entity 'thrombotic microangiopathy' named entity 'thromboembolic disease' named entity 'ICU' named entity 'intensive care unit' named entity 'viscoelastic' named entity 'Clot lysis' named entity 'lupus anticoagulant' named entity 'patient outcomes' named entity 'normal range' named entity 'coagulation' named entity 'SARS-CoV-2' named entity 'endogenous proteins' named entity 'COVID' named entity 'subcutaneously' named entity 'hospital discharge' named entity 'cohort study' named entity 'hypercoagulability' named entity 'thrombus' named entity 'COVID' named entity 'post-mortem' named entity 'coagulation' named entity 'intensive care units' named entity 'endogenous' named entity 'pro-coagulant' named entity 'respiratory failure' named entity 'comorbidity' named entity 'prothrombotic' named entity 'renal replacement therapy' named entity 'COVID' named entity 'COVID' named entity 'anticoagulation' named entity 'infection' named entity 'intensive care unit' named entity 'Coagulation' named entity 'coagulation' named entity 'point of care' named entity 'clotting tendency' named entity 'pro-coagulant' named entity 'Viscoelastic' named entity 'COVID' named entity 'COVID' named entity 'clinical data' named entity 'thromboembolic complications' named entity 'extra-corporeal membrane oxygenation' named entity 'hypercoagulable state' named entity 'point prevalence'

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