About: TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

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About: TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine
Creator	Farzan, Michael Bu, Xia Choe, Hyeryun Jemielity, Stephanie Li, Wenhui Monahan, Sheena Chan, Ying Freeman, Gordon Ahmed, Asim Umetsu, Dale Wang, Jinyize Dekruyff, Rosemarie
Source	Medline; PMC
abstract	Human T-cell Immunoglobulin and Mucin-domain containing proteins (TIM1, 3, and 4) specifically bind phosphatidylserine (PS). TIM1 has been proposed to serve as a cellular receptor for hepatitis A virus and Ebola virus and as an entry factor for dengue virus. Here we show that TIM1 promotes infection of retroviruses and virus-like particles (VLPs) pseudotyped with a range of viral entry proteins, in particular those from the filovirus, flavivirus, New World arenavirus and alphavirus families. TIM1 also robustly enhanced the infection of replication-competent viruses from the same families, including dengue, Tacaribe, Sindbis and Ross River viruses. All interactions between TIM1 and pseudoviruses or VLPs were PS-mediated, as demonstrated with liposome blocking and TIM1 mutagenesis experiments. In addition, other PS-binding proteins, such as Axl and TIM4, promoted infection similarly to TIM1. Finally, the blocking of PS receptors on macrophages inhibited the entry of Ebola VLPs, suggesting that PS receptors can contribute to infection in physiologically relevant cells. Notably, infection mediated by the entry proteins of Lassa fever virus, influenza A virus and SARS coronavirus was largely unaffected by TIM1 expression. Taken together our data show that TIM1 and related PS-binding proteins promote infection of diverse families of enveloped viruses, and may therefore be useful targets for broad-spectrum antiviral therapies.
has issue date	2013-03-28(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1003232
bibo:pmid	23555248
has license	cc-by
sha1sum (hex)	10a769cac0a76b41a6a82be148c1a2675e9d4604
schema:url	https://doi.org/10.1371/journal.ppat.1003232
resource representing a document's title	TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine
has PubMed Central identifier	PMC3610696
has PubMed identifier	23555248
schema:publication	PLoS Pathog
resource representing a document's body	covid:10a769cac0a76b41a6a82be148c1a2675e9d4604#body_text
is schema:about of	named entity 'FAMILY' named entity 'viral entry' named entity 'infection' named entity 'enhanced' named entity 'broad-spectrum' named entity 'cells' named entity 'particles' named entity 'families' named entity 'VIRUSES' covid:arg/10a769cac0a76b41a6a82be148c1a2675e9d4604 named entity 'ALPHAVIRUS' named entity 'INFECTION' named entity 'RETROVIRUSES' named entity 'MEDIATED' named entity 'LASSA FEVER VIRUS' named entity 'INFLUENZA A VIRUS' named entity 'DATA' named entity 'HUMAN' named entity 'MUTAGENESIS' named entity 'EXPRESSION' named entity 'RELEVANT' named entity 'INTERACTIONS' named entity 'ENHANCED' named entity 'CONTAINING' named entity 'EBOLA VIRUS' named entity 'VIRUS-LIKE PARTICLES' named entity 'CELLULAR' named entity 'ENTRY' named entity 'T-CELL' named entity 'TIM1' named entity 'PROMOTE' named entity 'PROPOSED' named entity 'FILOVIRUS' named entity 'PARTICULAR' named entity 'VIRAL ENTRY' named entity 'LARGELY' named entity 'TO SERVE AS' named entity 'EXPERIMENTS' named entity 'REPLICATION' named entity 'RECEPTOR' named entity 'RELATED' named entity 'ROSS RIVER' named entity 'VIRUSES' named entity 'FAMILIES' named entity 'COMPETENT' named entity 'NEW WORLD ARENAVIRUS' named entity 'RANGE' named entity 'TIM4' named entity 'EBOLA' named entity 'ASSOCIATED' named entity 'AXL' named entity 'SPECTRUM' named entity 'RECEPTORS' named entity 'IMMUNOGLOBULIN' named entity 'BIND' named entity 'THERAPIES' named entity 'BLOCKING' named entity 'PHOSPHATIDYLSERINE' named entity 'PROTEINS' named entity 'VIRION' named entity 'SARS CORONAVIRUS' named entity 'INHIBITED' named entity 'DEMONSTRATED' named entity 'PROTEINS' named entity 'DENGUE' named entity 'ADDITION' named entity 'DENGUE VIRUS' named entity 'MUCIN' named entity 'MACROPHAGES' named entity 'HERE'

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