About: Neutrophil extracellular traps and thrombosis in COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neutrophil extracellular traps and thrombosis in COVID-19
Creator	Shi, Hui Gockman, Kelsey Kanthi, Yogendra Knight, Jason Madison, Jacqueline Yalavarthi, Srilakshmi Zuo, Melanie Zuo, Yu
Source	MedRxiv; Medline
abstract	Here, we report on four patients whose hospitalizations for COVID-19 were complicated by venous thromboembolism (VTE). All demonstrated high levels of D-dimer as well as high neutrophil-to-lymphocyte ratios. For three patients, we were able to test sera for neutrophil extracellular trap (NET) remnants and found significantly elevated levels of cell-free DNA, myeloperoxidase-DNA complexes, and citrullinated histone H3. Neutrophil-derived S100A8/A9 (calprotectin) was also elevated. Given strong links between hyperactive neutrophils, NET release, and thrombosis in many inflammatory diseases, the potential relationship between NETs and VTE should be further investigated in COVID-19.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.30.20086736
bibo:pmid	32511553
has license	medrxiv
sha1sum (hex)	109ca563e82920a33fea13c1080ae969c0109df8
schema:url	https://doi.org/10.1101/2020.04.30.20086736
resource representing a document's title	Neutrophil extracellular traps and thrombosis in COVID-19
has PubMed identifier	32511553
schema:publication	medRxiv : the preprint server for health sciences
resource representing a document's body	covid:109ca563e82920a33fea13c1080ae969c0109df8#body_text
is schema:about of	named entity 'DNA' named entity 'S100A8' named entity 'COVID-19' named entity 'COMPLEXES' named entity 'sera' named entity 'neutrophil' named entity 'S100A8' named entity 'lymphocyte' named entity 'Neutrophil' named entity 'high levels' named entity 'VTE' named entity 'cell-free DNA' named entity 'venous thromboembolism' named entity 'Neutrophil extracellular traps' named entity 'thrombosis' named entity 'NETs' named entity 'acute respiratory distress syndrome' named entity 'cytotoxic' named entity 'influenza-like illness' named entity 'NETs' named entity 'medRxiv' named entity 'myeloperoxidase' named entity 'monocytes' named entity 'S100A8' named entity 'neutrophil' named entity 'nitric oxide synthase' named entity 'arteries' named entity 'jhu.edu' named entity 'peer review' named entity 'NETs' named entity 'heparin' named entity 'mechanical ventilation' named entity 'histone H3' named entity 'Neutrophil' named entity 'deep vein thrombosis' named entity 'histones' named entity 'thrombosis' named entity 'thrombosis' named entity 'antiphospholipid antibodies' named entity 'neutrophil' named entity 'peer review' named entity 'NETs' named entity 'inflammation' named entity 'thrombotic disease' named entity 'neutrophil' named entity 'neutrophils' named entity 'VTE' named entity 'NETs' named entity 'cardiovascular disease' named entity 'biochemical' named entity 'peer review' named entity 'extracellular' named entity 'microvessels' named entity 'peer review' named entity 'hyperactivity' named entity 'VTE' named entity 'myeloperoxidase' named entity 'NETs' named entity 'Serine proteases' named entity 'NADPH oxidase' named entity 'prophylactic' named entity 'medRxiv' named entity 'neutrophil' named entity 'cell-free DNA' named entity 'deep vein thrombosis' named entity 'antibodies' named entity 'peptidylarginine deiminase' named entity 'inflammatory diseases' named entity 'tissue factor pathway inhibitor' named entity 'myeloperoxidase' named entity 'NETs' named entity 'COVID-19' named entity 'COVID' named entity 'antiphospholipid antibodies' named entity 'anticoagulation'

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