About: Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
Creator	Bauer, G Cinatl, J Morgenstern, B Rabenau, H Doerr, H Michaelis, M Preiser, W Hoever, G Hofmann, W.-K Vogel, J.-U
Source	Medline; PMC
abstract	To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.
has issue date	2004-01-01(xsd:dateTime)
bibo:doi	10.1007/s00018-004-4222-9
bibo:pmid	15316659
has license	no-cc
sha1sum (hex)	109974d5ee96b2e0c4d14b314d4d415dfb1578bc
schema:url	https://doi.org/10.1007/s00018-004-4222-9
resource representing a document's title	Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus
has PubMed Central identifier	PMC7079841
has PubMed identifier	15316659
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:109974d5ee96b2e0c4d14b314d4d415dfb1578bc#body_text
is schema:about of	named entity 'pathogenesis' named entity 'oligonucleotide' named entity 'tested' named entity 'CL-14' named entity 'SENSITIVITY' named entity 'HIGH-DENSITY' named entity 'CELL LINES' named entity 'INTESTINAL' named entity 'CMLS' named entity 'CACO-2' named entity 'MODEL' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'STUDY' named entity 'CELLULAR' named entity 'GENE EXPRESSION' named entity 'INFECTION' named entity 'SARS CORONAVIRUS' named entity 'OLIGONUCLEOTIDE ARRAYS' named entity 'USING' named entity 'TESTED' named entity 'PATHOGENESIS' named entity 'INTESTINAL EPITHELIAL CELL' named entity 'TO IDENTIFY' named entity 'EFFECTS' named entity 'HUMAN' covid:arg/109974d5ee96b2e0c4d14b314d4d415dfb1578bc named entity 'arrays' named entity 'Caco-2' named entity 'pathogenesis' named entity 'severe acute respiratory syndrome' named entity 'oligonucleotide' named entity 'intestinal epithelial cell' named entity 'cell lines' named entity 'Caco-2' named entity 'ACE2' named entity 'AP-1' named entity 'Affymetrix' named entity 'c-Fos' named entity 'Genetics' named entity 'murine' named entity 'Seelze' named entity 'chemokines' named entity 'SARS-CoV' named entity 'ACE2' named entity 'Caco-2' named entity 'infection' named entity 'tropism' named entity 'infection' named entity 'chemokines' named entity 'apoptotic' named entity 'apoptosis' named entity 'intestinal cells' named entity 'Microarray Analysis' named entity 'apoptosis' named entity 'electron microscopy' named entity 'constitutively expressed' named entity 'microscopic appearance' named entity 'OAS2' named entity 'infection' named entity 'Japan' named entity 'gene expression' named entity 'virus' named entity 'liver' named entity 'IFN' named entity 'CXC chemokines' named entity 'methanol' named entity 'goat' named entity 'intestinal cells' named entity 'SARS-CoV' named entity 'cytoplasm' named entity 'Rotavirus' named entity 'Miame'

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