About: Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization

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About: Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization
Creator	Zhao, Hui Deng, Yong-Qiang Qin, Cheng-Feng Jiang, Tao Li, Xiao-Feng Liu, Zhong-Yu Ye, Qing Yu, Jiu-Yang
Source	PMC
abstract	Viral replicase recruitment and long-range RNA interactions are essential for RNA virus replication, yet the mechanism of their interplay remains elusive. Flaviviruses include numerous important human pathogens, e.g., dengue virus (DENV) and Zika virus (ZIKV). Here, we revealed a highly conserved, conformation-tunable cis-acting element named 5′-UAR-flanking stem (UFS) in the flavivirus genomic 5′ terminus. We demonstrated that the UFS was critical for efficient NS5 recruitment and viral RNA synthesis in different flaviviruses. Interestingly, stabilization of the DENV UFS impaired both genome cyclization and vRNA replication. Moreover, the UFS unwound in response to genome cyclization, leading to the decreased affinity of NS5 for the viral 5′ end. Thus, we propose that the UFS is switched by genome cyclization to regulate dynamic RdRp binding for vRNA replication. This study demonstrates that the UFS enables communication between flavivirus genome cyclization and RdRp recruitment, highlighting the presence of switch-like mechanisms among RNA viruses. DOI: http://dx.doi.org/10.7554/eLife.17636.001
has issue date	2016-10-01(xsd:dateTime)
bibo:doi	10.7554/elife.17636
bibo:pmid	27692070
has license	cc-by
sha1sum (hex)	10978f83e192204ea4f2347d49886969558a8b99
schema:url	https://doi.org/10.7554/elife.17636
resource representing a document's title	Viral RNA switch mediates the dynamic control of flavivirus replicase recruitment by genome cyclization
has PubMed Central identifier	PMC5101012
has PubMed identifier	27692070
resource representing a document's body	covid:10978f83e192204ea4f2347d49886969558a8b99#body_text
is schema:about of	named entity 'RECRUITMENT' named entity 'MEDIATES' named entity 'RNA virus' named entity 'human' named entity 'regulate' named entity 'mechanisms' named entity 'flavivirus' named entity 'DENV' named entity 'Viral' named entity 'SWITCH' covid:arg/10978f83e192204ea4f2347d49886969558a8b99 named entity 'CONTROL' named entity 'FLAVIVIRUS' named entity 'RANGE' named entity 'IMPAIRED' named entity 'LEADING' named entity 'VRNA' named entity 'DECREASED AFFINITY' named entity 'CIS-ACTING ELEMENT' named entity 'INCLUDE' named entity 'THEIR' named entity 'RNA' named entity 'REVEALED' named entity 'GENOMIC' named entity 'COMMUNICATION' named entity 'CRITICAL' named entity 'RESPONSE TO' named entity 'SWITCHED' named entity 'CONFORMATION' named entity 'HUMAN' named entity 'HIGHLY' named entity 'REPLICATION' named entity 'ENABLES' named entity 'REPLICASE' named entity 'DEMONSTRATED' named entity 'RNA SYNTHESIS' named entity 'MECHANISMS' named entity 'EFFICIENT' named entity 'DIFFERENT' named entity 'NS5' named entity 'NAMED' named entity 'MECHANISM' named entity 'END' named entity 'NUMEROUS' named entity 'INTERACTIONS' named entity 'STEM' named entity 'STUDY' named entity 'VIRUS REPLICATION' named entity 'RNA VIRUS' named entity 'LONG' named entity 'VIRAL RNA' named entity 'HERE' named entity 'LIKE' named entity 'FLAVIVIRUSES' named entity 'RDRP' named entity 'RECRUITMENT' named entity 'DYNAMIC' named entity 'PRESENCE OF' named entity 'SWITCH' named entity 'ZIKA VIRUS' named entity 'UFS' named entity 'VIRAL' named entity 'PATHOGENS' named entity 'TERMINUS' named entity 'GENOME' named entity 'FLAVIVIRUS' named entity 'CYCLIZATION' named entity 'DYNAMIC' named entity 'GENOME' named entity 'IMPORTANT' named entity 'UAR' named entity 'HIGHLIGHTING' named entity 'RNA VIRUSES' named entity 'BINDING' named entity 'CYCLIZATION'

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