About: The neurobiology of canine distemper virus infection

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About: The neurobiology of canine distemper virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The neurobiology of canine distemper virus infection
Creator	Zurbriggen, Andreas Vandevelde, Marc
Source	PMC
abstract	Canine distemper virus (CDV) invades the nervous system and replicates in neurons and glial cell of the white matter during a period of severe viral induced immunosuppression. Demyelination occurs in infected white matter areas in the absence of inflammation. The mechanism of demyelination is not apparent because there is no ultrastructural evidence of viral replication in the oligodendrocytes, the myelin producing cells. However, brain tissue culture studies have shown that oligodendrocytes support transcription of all CDV genes and later on degenerate, although no viral proteins can be found in these cells. It remains to be shown how such a restricted infection leads to demyelination. Concomitant with immunologic recovery during the further course of the disease, inflammation occurs in the demyelinating lesions with progression of the lesions in some animals. A series of experiments in vitro suggested that chronic demyelination is due to a bystander mechanism associated with the virus-induced immune response in which antibody dependent cell-mediated reactions play an important role. The progressive, or even relapsing, course of the disease is associated with viral persistence in the nervous system. Persistence of CDV in the brain appears to be due to non-cytolytic selective spread of the virus with very limited budding. In this way CDV escapes immune surveillance.
has issue date	2000-03-10(xsd:dateTime)
bibo:doi	10.1016/0378-1135(95)00021-2
bibo:pmid	8588322
has license	no-cc
sha1sum (hex)	0ffe9ea08fd22fd64f46cac7147c239e6af6543e
schema:url	https://doi.org/10.1016/0378-1135%2895%2900021-2
resource representing a document's title	The neurobiology of canine distemper virus infection
has PubMed Central identifier	PMC7117369
has PubMed identifier	8588322
schema:publication	Vet Microbiol
resource representing a document's body	covid:0ffe9ea08fd22fd64f46cac7147c239e6af6543e#body_text
is schema:about of	named entity 'immunosuppression' named entity 'glial cell' named entity 'virus' named entity 'immune response' named entity 'induced' named entity 'persistence' named entity 'disease' named entity 'REMAINS' named entity 'OLIGODENDROCYTES' named entity 'SELECTIVE' named entity 'ABSENCE OF' named entity 'NEURONS' named entity 'COURSE' named entity 'NON-' named entity 'CELL' named entity 'EVIDENCE OF' named entity 'MEDIATED' named entity 'HAVE' named entity 'IMPORTANT' named entity 'CDV' named entity 'RECOVERY' named entity 'PROGRESSION' named entity 'ROLE' named entity 'VIRAL REPLICATION' named entity 'ANIMALS' named entity 'STUDIES' named entity 'PERSISTENCE' named entity '135' named entity 'LATER' named entity 'IN VITRO' named entity 'IMMUNE SURVEILLANCE' named entity 'ANTIBODY' named entity 'WAY' named entity 'VIRAL' named entity 'LESIONS' named entity 'CHRONIC DEMYELINATION' named entity 'HOW' named entity 'RELAPSING' named entity 'CANINE DISTEMPER VIRUS' named entity 'NEUROBIOLOGY' named entity 'TISSUE CULTURE' named entity 'EXPERIMENTS' named entity 'IMMUNE RESPONSE' named entity 'INDUCED' named entity 'APPARENT' named entity 'GLIAL CELL' named entity 'CANINE DISTEMPER VIRUS' named entity 'DUE TO' named entity 'PROGRESSIVE' named entity 'DISEASE' named entity 'MECHANISM' named entity 'GENES' named entity 'THE BRAIN' named entity 'SPREAD' named entity 'IMMUNOLOGIC' named entity '1135' named entity 'SERIES' named entity 'ESCAPES' named entity 'BYSTANDER' named entity 'RESTRICTED' named entity 'THESE' named entity 'FAX' named entity 'VIRAL PROTEINS' named entity 'AREAS' named entity 'PRODUCING' named entity 'TRANSCRIPTION' named entity 'REPLICATES' named entity 'BRAIN TISSUE' named entity 'CONCOMITANT' named entity 'WHITE MATTER' named entity 'SEVERE' named entity 'DEPENDENT' named entity 'AUTHOR' named entity 'PERIOD' named entity 'VERY LIMITED' named entity 'PLAY' named entity 'NERVOUS SYSTEM' named entity 'RIGHTS' named entity 'FOUND' named entity 'INFECTED'

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