About: Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques
Creator	Lorin, Clarisse Vanloubbeeck, Yannick Rutvisuttinunt, Wiriya Jarman, Richard Vaughn, David Thomas, Stephen Gromowski, Gregory Garver, Lindsey Mores, Christopher Christofferson Id, Rebecca Currier, Jeffrey Goupil, Brad Hinton, Kevin Id, Heather Malice, Marie-Pierre Mccracken Id, Michael Putnak, J Walker, Kathryne Warter, Lucile
Source	PMC
abstract	Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were exposed to DENV-1 via subcutaneous or intradermal inoculation of virus only, intradermal inoculation of virus and salivary gland extract, or infectious mosquito feeding. The infectious mosquito feeding group exhibited delayed onset of viremia, greater viral loads, and altered clinical and immune responses compared to other groups. After 15 months, NHPs in the subcutaneous and infectious mosquito feeding groups were re-exposed to either DENV-1 or DENV-2. Viral replication and neutralizing antibody following homologous challenge were suggestive of sterilizing immunity, whereas heterologous challenge resulted in productive, yet reduced, DENV-2 replication and boosted neutralizing antibody. These results show that a more transmission-relevant exposure modality resulted in viral replication closer to that observed in humans.
has issue date	2020-04-08(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0008191
bibo:pmid	32267846
has license	cc0
sha1sum (hex)	0fdc7694db5cb27919527ac35059e5da0ceba547
schema:url	https://doi.org/10.1371/journal.pntd.0008191
resource representing a document's title	Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques
has PubMed Central identifier	PMC7141610
has PubMed identifier	32267846
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:0fdc7694db5cb27919527ac35059e5da0ceba547#body_text
is schema:about of	named entity 'mosquito' named entity 'virus' named entity 'proteins' named entity 'viral replication' named entity 'viremia' named entity 'mosquito' named entity 'EXAMINED' named entity 'FEEDING' named entity 'HOMOLOGOUS' named entity 'HETEROLOGOUS' named entity 'ALTERED' named entity 'THESE' named entity 'EXPOSED TO' named entity 'MONTHS' named entity 'EFFECT' named entity 'INTRADERMAL' named entity 'NONHUMAN PRIMATE' named entity 'TRANSMITTED BY' named entity 'subcutaneous' named entity 'compared' named entity 'homologous' named entity 'neutralizing antibody' named entity 'inoculation' named entity 'Dengue virus' named entity 'mosquito' named entity 'neutralizing antibody' named entity 'DENV' named entity 'rhesus macaques' named entity 'inoculation' named entity 'viral replication' named entity 'virus' named entity 'viremia' named entity 'rhesus macaques' named entity 'inoculation' named entity 'mosquito' named entity 'plaque assay' named entity 'WBC' named entity 'primer' named entity 'IMF' named entity 'DENV' named entity 'ANOVA' named entity 'statistical analysis' named entity 'DENV' named entity 'virus' named entity 'Raritan, NJ' named entity 'cytokines' named entity 'hematological' named entity 'cytokine' named entity 'DENV' named entity 'fixed effects' named entity 'platelet' named entity 'IMF' named entity 'IL-2' named entity 'humidified' named entity 'IMF' named entity 'salivary gland' named entity 'macaques' named entity 'IMF' named entity 'p-values' named entity 'dengue fever' named entity 'DENV' named entity 'IMF' named entity 'fluorophore'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software