About: The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis

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About: The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis
Creator	Ramdasi, Ashwini Id, Vidya
source	PMC
abstract	Hepatitis E is an enteric disease highly prevalent in the developing countries. The basis for high mortality among pregnant hepatitis E patients remains unclear. Importantly, a large proportion of infected pregnant women present with subclinical infection as well. In order to understand the possible mechanisms influencing clinical presentation of hepatitis E in pregnant women, we explored a system biology approach. For this, PBMCs from various categories were subjected to RNAseq analysis. These included non-pregnant (NPR, acute and convalescent phases) and pregnant (PR, 2(nd) and 3(rd) trimesters, acute phase and subclinical HEV infections) patients and corresponding healthy controls. The current study deals with immune response genes. In contrast to exclusive up-regulation of nonspecific, early immune response transcripts in the NPR patients, the PR patients exhibited broader and heightened expression of genes associated with innate as well as adaptive T and B cell responses. The study identified for the first time (1) inverse relationship of immunoglobulin (Ig) genes overexpression and (2) association of differential expression of S100 series genes with disease presentation. The data suggests possible involvement of TLR4 and NOD1 in pregnant patients and alpha defensins in all patient categories suggesting a role in protection. Induction of IFNγ gene was not detected during the acute phase irrespective of pregnancy. Association of response to vitamin D, transcripts related to NK/NKT and regulatory T cells during subclinical infection are noteworthy. The data obtained here could be correlated with several studies reported earlier in hepatitis E patients suggesting utility of PBMCs as an alternate specimen. The extensive, informative data provided here for the first time should form basis for future studies that will help in understanding pathogenesis of fulminant hepatitis E.
has issue date	2020-02-03(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0228068
bibo:pmid	32012176
has license	cc-by
sha1sum (hex)	0fdba4c24e81ec738a498e2ffa501d46c22745a6
schema:url	https://doi.org/10.1371/journal.pone.0228068
resource representing a document's title	The expression patterns of immune response genes in the Peripheral Blood Mononuclear cells of pregnant women presenting with subclinical or clinical HEV infection are different and trimester-dependent: A whole transcriptome analysis
has PubMed Central identifier	PMC6996850
has PubMed identifier	32012176
schema:publication	PLoS One
resource representing a document's body	covid:0fdba4c24e81ec738a498e2ffa501d46c22745a6#body_text
is schema:about of	named entity 'THESE' named entity 'DISEASE' named entity 'INFECTED' named entity 'DEVELOPING COUNTRIES' named entity 'CATEGORIES' named entity 'NON-' named entity 'PREGNANT' named entity 'GENES' named entity 'CLINICAL' named entity 'cells' named entity 'Blood' named entity 'DEPENDENT' named entity 'INCLUDED' named entity 'HEPATITIS E' named entity 'ORDER' named entity 'UNDERSTAND' named entity 'BASIS' named entity 'PATIENTS' named entity 'SUBCLINICAL' named entity 'POSSIBLE' named entity 'RNASEQ' named entity 'IMMUNE RESPONSE' named entity 'HEV' named entity 'PBMCS' named entity 'HEALTHY' named entity 'IMMUNE RESPONSE' named entity 'PREGNANT WOMEN' named entity 'PATTERNS' named entity 'DIFFERENT' named entity 'EXPRESSION' named entity 'INFECTION' named entity 'HEV' named entity 'WHOLE TRANSCRIPTOME' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'TRIMESTER' named entity 'SUBCLINICAL' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'TRIMESTERS' named entity 'INFECTIONS' named entity 'PREVALENT' named entity 'HIGHLY' named entity 'HIGH' named entity 'LARGE' named entity 'CLINICAL PRESENTATION' named entity 'PREGNANT WOMEN' named entity 'PRESENT' named entity 'MORTALITY' named entity 'GENES' named entity 'ACUTE' named entity 'UNCLEAR' named entity 'CONVALESCENT' named entity 'ACUTE PHASE' named entity 'PRESENTING' named entity 'APPROACH' named entity 'ENTERIC' named entity 'MECHANISMS' named entity 'ANALYSIS' named entity 'SUBCLINICAL INFECTION' named entity 'PHASES' named entity 'CURRENT' named entity 'PROPORTION' named entity 'SYSTEM BIOLOGY' named entity 'STUDY' named entity 'VARIOUS' covid:arg/0fdba4c24e81ec738a498e2ffa501d46c22745a6 named entity 'basis' named entity 'mechanisms' named entity 'patients' named entity 'current' named entity 'highly' named entity 'controls' named entity 'subclinical' named entity 'presenting' named entity 'NPR' named entity 'pregnant women' named entity 'subclinical' named entity 'enteric disease' named entity 'subclinical infection' named entity 'developing countries' named entity 'Peripheral Blood Mononuclear cells'

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