About: Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue‐experienced Chinese patients with chronic HBV infection

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About: Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue‐experienced Chinese patients with chronic HBV infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue‐experienced Chinese patients with chronic HBV infection
Creator	Liu, Y Wang, L Zhang, L Li, L Li, X Ren, X Wang, C Xu, D Xu, Z Yao, Z Zhong, Y Dai, J Ji, D Wong, -S Zoulim, F
Source	Medline; PMC
abstract	Summary. The study investigated the hepatitis B virus (HBV) genotypic resistance profile in 1803 nucleos(t)ide analogue (NA)‐experienced Chinese patients with chronic HBV infection. Serum HBV DNA was extracted, and the reverse transcriptase region was analysed by a high‐sensitive direct PCR sequencing and verified by clonal sequencing if necessary. Drug‐resistant mutations were detected in 560 of the 1803 patients, including 214 of 490 patients who received lamivudine (LAM), 35 of 428 patients who received adefovir (ADV), five of 18 patients who received telbivudine and 306 of 794 patients who received various sequential/combined NA therapies. ADV‐resistant mutations were detected in 36 of 381 patients who received LAM and then switched‐to ADV in contrast to one of 82 patients who received ADV add‐on LAM. Entecavir (ETV)‐resistant mutations were detected not only in LAM‐ and ETV‐treated patients but also in LAM‐treated ETV‐naïve patients. Double mutations rtM204I and rtL180M were detected more frequently in genotype C than in genotype B virus, and patients infected with this mutant had higher alanine transaminase levels than those infected with mutant containing the rtM204I substitution alone. Multidrug‐resistant HBV strains were identified in eight patients, including two novel strains with mutational patterns rtL180M + A181V + S202G + M204V + N236T and rtL180M + S202G + M204V + N236T. The results provide new information on HBV genotypic resistance profiles in a large cohort of Chinese patients with chronic HBV infection and may have important clinical implication for HBV drug resistance management in China.
has issue date	2010-09-06(xsd:dateTime)
bibo:doi	10.1111/j.1365-2893.2010.01360.x
bibo:pmid	21392168
has license	no-cc
sha1sum (hex)	0f9c43aca920761d4e91a8e9a859a50a9408534c
schema:url	https://doi.org/10.1111/j.1365-2893.2010.01360.x
resource representing a document's title	Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue‐experienced Chinese patients with chronic HBV infection
has PubMed Central identifier	PMC7167191
has PubMed identifier	21392168
schema:publication	J Viral Hepat
resource representing a document's body	covid:0f9c43aca920761d4e91a8e9a859a50a9408534c#body_text
is schema:about of	named entity 'patients' named entity 'combined' named entity 'Chinese' named entity 'detected' named entity 'detected' named entity 'extracted' named entity 'ADV' named entity 'HBV' named entity 'hepatitis B virus' named entity 'chronic HBV' named entity 'China' named entity 'mutant' named entity 'received' named entity 'region' named entity 'virus' named entity 'received' named entity 'reverse transcriptase' named entity 'genotype' named entity 'mutant' named entity 'Serum' named entity 'PCR' named entity 'patients' named entity 'alanine transaminase' named entity 'Multidrug-resistant' named entity 'HBV' named entity 'adefovir' named entity 'virus' named entity 'HBV' named entity 'HBV' named entity 'chronic HBV' named entity 'hepatitis B virus' named entity 'HBV' named entity 'Genotypic' named entity 'ADV' named entity 'HBV' named entity 'virologic' named entity 'entecavir' named entity 'PCR' named entity 'HBV' named entity 'HBV' named entity 'CHB' named entity 'PCR' named entity 'HBV' named entity 'Cross-resistance' named entity 'Vector NTI' named entity 'China' named entity 'adefovir' named entity 'potency' named entity 'DNA Analyzer' named entity 'wild-type' named entity 'genotype' named entity 'detection limit' named entity 'virus replication' named entity 'telbivudine' named entity 'China' named entity 'resistant mutations' named entity 'nested PCR' named entity 'nucleotide analogues' named entity 'primers' named entity 'virologic' named entity 'HBV' named entity 'gene' named entity 'Beijing' named entity 'PCR' named entity 'resistant mutations' named entity 'antiviral' named entity 'antiviral'

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