About: Molecular testing for respiratory pathogens in sickle cell disease adult patients presenting with febrile acute chest syndrome

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About: Molecular testing for respiratory pathogens in sickle cell disease adult patients presenting with febrile acute chest syndrome Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular testing for respiratory pathogens in sickle cell disease adult patients presenting with febrile acute chest syndrome
Creator	Audureau, E Bartolucci, P Decousser, J Fourati, S Gallien, S »more»
source	Elsevier; Medline; PMC
abstract	Abstract Background Differentiating acute chest syndrome (ACS) from community-acquired pneumonia (CAP) is challenging in adults presenting with major sickle cell disease (SCD) (semiological similarity, rare microbiological documentation). We aimed to assess the usefulness of nucleic acid amplification test (NAAT) for respiratory pathogens, in combination with standard bacteriological investigations, in febrile ACS adult patients presenting with major SCD. Methods We performed a prospective, monocentric, observational study of 61 SCD adults presenting with febrile ACS from February 2015 to April 2016. Systematic blood, urine, and respiratory specimens were collected, before antibiotic initiation, for culture, urinary antigen tests, serology, and NAAT for respiratory pathogens. Results A pathogen was detected in 12 febrile ACS (19.7%): four viruses (6.6%) (Rhinovirus; Influenza A/B), seven bacteria (11.4%) (S. aureus, S. pneumoniae, K. pneumoniae, L. pneumophila, M. pneumoniae), one mixed infection (1.6%) (S. aureus and Influenza B). NAAT only detected L. pneumophila in one case (serogroup 2). Apart from a significantly shorter antibiotic therapy duration (6.1 vs. 7.8 days, P =0.045), no difference was observed between undocumented and microbiologically-documented febrile ACS. Conclusion Using NAAT for the detection of respiratory pathogens in adults presenting with SCD slightly improved the microbiological diagnostic of febrile ACS, although respiratory infections are not the main etiological factor.
has issue date	2020-02-29(xsd:dateTime)
bibo:doi	10.1016/j.medmal.2019.04.391
bibo:pmid	31088757
has license	els-covid
sha1sum (hex)	0f708595e4628dc58164414bd6acf9f9df6c0ba8
schema:url	https://doi.org/10.1016/j.medmal.2019.04.391
resource representing a document's title	Molecular testing for respiratory pathogens in sickle cell disease adult patients presenting with febrile acute chest syndrome
has PubMed Central identifier	PMC7127005
has PubMed identifier	31088757
schema:publication	Médecine et Maladies Infectieuses
resource representing a document's body	covid:0f708595e4628dc58164414bd6acf9f9df6c0ba8#body_text
is schema:about of	named entity 'presenting' named entity 'sickle cell disease' named entity 'LES' named entity 'CHEZ' named entity 'EST' »more»

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