About: Seoul Virus Tropism and Pathology in Naturally Infected Feeder Rats

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Seoul Virus Tropism and Pathology in Naturally Infected Feeder Rats
Creator	Kuiken, Thijs Rockx, Barry Hoornweg, Tabitha Maas, Miriam De Vries, Ankje Kroeze, Edwin Van Heteren, Melanie
source	PMC
abstract	Seoul virus (SEOV) is a zoonotic orthohantavirus carried by black and brown rats, and can cause hemorrhagic fever with renal syndrome in humans. Human cases of SEOV virus infection have most recently been reported in the USA, United Kingdom, France and the Netherlands and were primarily associated with contact with pet rats and feeder rats. Infection of rats results in an asymptomatic but persistent infection. Little is known about the cell tropism of SEOV in its reservoir and most available data is based on experimental infection studies in which rats were inoculated via a route which does not recapitulate virus transmission in nature. Here we report the histopathological analysis of SEOV cell tropism in key target organs following natural infection of a cohort of feeder rats, comprising 19 adults and 11 juveniles. All adult rats in this study were positive for SEOV specific antibodies and viral RNA in their tissues. One juvenile rat was seropositive, but negative in the rRT-PCR. Of the 19 adult rats of which subsequently additional organs were tested, SEOV RNA was detected in all lungs, followed by kidney (79%) and liver (74%). Histopathologic changes associated with SEOV infection were primarily found in the liver, consistent with a pathological diagnosis of a mild hepatitis. In conclusion, natural SEOV infection results in mild inflammation of the liver in the absence of clinical disease.
has issue date	2019-06-07(xsd:dateTime)
bibo:doi	10.3390/v11060531
bibo:pmid	31181690
has license	cc-by
sha1sum (hex)	0f45da571ca739a0ec5c818fa2d39025398673d7
schema:url	https://doi.org/10.3390/v11060531
resource representing a document's title	Seoul Virus Tropism and Pathology in Naturally Infected Feeder Rats
has PubMed Central identifier	PMC6630879
has PubMed identifier	31181690
schema:publication	Viruses
resource representing a document's body	covid:0f45da571ca739a0ec5c818fa2d39025398673d7#body_text
is schema:about of	named entity 'contact' named entity 'hemorrhagic fever' named entity 'rats' named entity 'pathological' named entity 'cohort' named entity 'rats' named entity 'consistent' named entity 'Infected' named entity 'Pathology' named entity 'MILD' named entity 'SEOUL VIRUS' named entity 'DATA' named entity 'CONTACT WITH' named entity 'UNITED KINGDOM' named entity 'ORGANS' named entity 'NATURAL INFECTION' named entity 'ABOUT' named entity 'FRANCE' named entity 'ASYMPTOMATIC' named entity 'KEY' named entity 'REPORT' named entity 'CARRIED' named entity 'STUDY' named entity 'SEROPOSITIVE' named entity 'CELL' named entity 'PERSISTENT INFECTION' named entity 'TARGET' named entity 'ANTIBODIES' named entity 'TESTED' named entity 'HISTOPATHOLOGICAL' named entity 'STUDIES' named entity 'CAUSE' named entity 'RECENTLY' named entity 'FOLLOWED BY' named entity 'SPECIFIC' named entity 'THE NETHERLANDS' named entity 'ADULTS' named entity 'THE CELL' named entity 'LUNGS' named entity 'REPORTED' named entity 'DETECTED' named entity 'USA' named entity 'FOLLOWING' named entity 'WITH CONTACT' named entity 'HISTOPATHOLOGIC' named entity 'MILD INFLAMMATION' named entity 'COHORT' named entity 'FEEDER' named entity 'RESULTS' named entity 'DOES NOT' named entity 'DIAGNOSIS' named entity 'VIRUS INFECTION' named entity 'TRANSMISSION' named entity 'RATS' named entity 'RNA' named entity 'CONCLUSION' named entity 'HAVE' named entity 'CONSISTENT WITH' named entity 'AVAILABLE' named entity 'NATURAL' named entity 'LIVER' named entity 'KNOWN' named entity 'HUMAN' named entity 'VIRUS TROPISM' named entity 'FEEDER' named entity 'RATS' named entity 'INFECTED' named entity 'PATHOLOGY' named entity 'SEOUL VIRUS' named entity 'VIRUS' named entity 'IS A' named entity 'CLINICAL' named entity 'ASSOCIATED WITH' named entity 'TROPISM' named entity 'HERE'

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