About: STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

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About: STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters
Creator	Schols, Dominique Neyts, Johan Heylen, Elisabeth Wang, Xinyu Jochmans, Dirk Leyssen, Pieter Wang, Zhongde Delang, Leen Rocha-Pereira, Joana Li, Rong Liu, Yanan Vanmechelen, Bert Kaptein, Suzanne Thibaut, Hendrik Weyenbergh, Johan Chiu, Winston Dallmeier, Kai Bervoets, Lindsey Cawthorne, Christopher Coelmont, Lotte De Keyzer, Carolien Liesenborghs, Laurens Ma, Ji Seldeslachts, Laura Sharma, Sapna Vercruysse, Thomas Boudewijns, Robbert Jacobs, Sofie Jansen, Sander Looveren, Dominique Martí-Carreras, Joan Van Buyten, Tina Vande Velde, Greetje Vergote, Valentijn Wang, Lanjiao Wawina-Bokalanga, Tony
Source	BioRxiv
abstract	Since the emergence of SARS-CoV-2 causing COVID-19, the world is being shaken to its core with numerous hospitalizations and hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that productive SARS-CoV-2 infection in the lungs of mice is limited and restricted by early type I interferon responses. In contrast, we show that Syrian hamsters are highly permissive to SARS- CoV-2 and develop bronchopneumonia and a strong inflammatory response in the lungs with neutrophil infiltration and edema. Moreover, we identify an exuberant innate immune response as a key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Finally, we assess SARS-CoV- 2-induced lung pathology in hamsters by micro-CT alike used in clinical practice. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
has issue date	2020-07-02(xsd:dateTime)
bibo:doi	10.1101/2020.04.23.056838
has license	biorxiv
sha1sum (hex)	0eab90c85a55a8c8c0d73405a403f1a20bcbbb87
schema:url	https://doi.org/10.1101/2020.04.23.056838
resource representing a document's title	STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters
schema:publication	bioRxiv
resource representing a document's body	covid:0eab90c85a55a8c8c0d73405a403f1a20bcbbb87#body_text
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