About: Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice
Creator	Xia, Xianzhu Yang, Songtao Wang, Chong Yan, Jinghua Li, Nan Wong, Gary Feng, Na Gai, Weiwei Gao, Yuwei Wang, Hualei Zhao, Yongkun Zheng, Xuexing Zhang, Weijiao Jin, Hongli Hu, Guixue Li, Junfu Zhao, Guoxing
Source	Elsevier; Medline; PMC
abstract	Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat. Prophylactics and therapies are urgently needed to address this public health problem. We report here the efficacy of a vaccine consisting of chimeric virus-like particles (VLP) expressing the receptor binding domain (RBD) of MERS-CoV. In this study, a fusion of the canine parvovirus (CPV) VP2 structural protein gene with the RBD of MERS-CoV can self-assemble into chimeric, spherical VLP (sVLP). sVLP retained certain parvovirus characteristics, such as the ability to agglutinate pig erythrocytes, and structural morphology similar to CPV virions. Immunization with sVLP induced RBD-specific humoral and cellular immune responses in mice. sVLP-specific antisera from these animals were able to prevent pseudotyped MERS-CoV entry into susceptible cells, with neutralizing antibody titers reaching 1: 320. IFN-γ, IL-4 and IL-2 secreting cells induced by the RBD were detected in the splenocytes of vaccinated mice by ELISpot. Furthermore, mice inoculated with sVLP or an adjuvanted sVLP vaccine elicited T-helper 1 (Th1) and T-helper 2 (Th2) cell-mediated immunity. Our study demonstrates that sVLP displaying the RBD of MERS-CoV are promising prophylactic candidates against MERS-CoV in a potential outbreak situation.
has issue date	2017-04-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2016.12.019
bibo:pmid	28040513
has license	els-covid
sha1sum (hex)	0ea86045c0a8a03ce313440eb1e887f26a85cae3
schema:url	https://doi.org/10.1016/j.antiviral.2016.12.019
resource representing a document's title	Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice
has PubMed Central identifier	PMC7113847
has PubMed identifier	28040513
schema:publication	Antiviral Research
resource representing a document's body	covid:0ea86045c0a8a03ce313440eb1e887f26a85cae3#body_text
is schema:about of	named entity 'susceptible' named entity 'morphology' named entity 'Th1' named entity 'Immunization' named entity 'structural' named entity 'CPV' named entity 'promising' named entity 'problem' named entity 'domain' named entity 'Novel' named entity 'MERS-COV' named entity 'ADJUVANTED' named entity 'SECRETING' named entity 'IS A' named entity 'EMERGENCE' named entity 'CHARACTERISTICS' named entity 'VACCINE' named entity 'CANINE PARVOVIRUS' named entity 'NEUTRALIZING ANTIBODY' named entity 'VIRUS-LIKE PARTICLES' named entity 'SPREADING' named entity 'STRUCTURAL' named entity 'INDUCE' named entity 'ENTRY' named entity 'THREAT' named entity 'PARVOVIRUS' named entity 'SITUATION' named entity 'FUSION' named entity 'THESE' named entity 'CELLULAR IMMUNE RESPONSE' named entity 'BINDING' named entity 'VIRUS-LIKE PARTICLES' named entity 'MICE' named entity 'CHIMERIC VIRUS' named entity 'RECEPTOR' named entity 'NOVEL' named entity 'DOMAIN' named entity 'DISPLAYING' named entity 'VACCINE' named entity 'SPECIFIC' named entity 'PIG' named entity 'VLP' named entity 'CELLS' named entity 'IMMUNE RESPONSES' named entity 'ASSEMBLE' named entity 'DOMAIN' named entity 'HERE' named entity 'VACCINATED' named entity 'IL-2' named entity 'SPECIFIC' named entity 'POTENTIAL' named entity 'EFFICACY' named entity 'MORTALITY RATE' named entity 'REACHING' named entity 'IL-4' named entity 'PROPHYLACTIC' named entity 'INDUCED' named entity 'CHIMERIC' named entity 'SIMILAR' named entity 'STRUCTURAL PROTEIN GENE' named entity 'MICE' named entity 'RETAINED' named entity 'VIRIONS' named entity 'IMMUNIZATION' named entity 'STUDY'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software