About: A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro
Creator	Cao, Zhijian Li, Wenxin Wu, Yingliang Zhang, Qian Liu, Yun Hong, Wei Zeng, Zhengyang Xie, Yingqiu
Source	Medline; PMC
abstract	Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). Nowadays, clinical therapies of HBV infection still mainly rely on nucleotide analogs and interferons, the usage of which is limited by drug-resistant mutation or side effects. Defensins had been reported to effectively inhibit the proliferation of bacteria, fungi, parasites and viruses. Here, we screened the anti-HBV activity of 25 scorpion-derived peptides most recently characterized by our group. Through evaluating anti-HBV activity and cytotoxicity, we found that BmKDfsin4, a scorpion defensin with antibacterial and Kv1.3-blocking activities, has a comparable high inhibitory rate of both HBeAg and HBsAg in HepG2.2.15 culture medium and low cytotoxicity to HepG2.2.15. Then, our experimental results further showed that BmKDfsin4 can dose-dependently decrease the production of HBV DNA and HBV viral proteins in both culture medium and cell lysate. Interestingly, BmKDfsin4 exerted high serum stability. Together, this study indicates that the scorpion defensin BmKDfsin4 also has inhibitory activity against HBV replication along with its antibacterial and potassium ion channel Kv1.3-blocking activities, which shows that BmKDfsin4 is a uniquely multifunctional defensin molecule. Our work also provides a good molecule material which will be used to investigate the link or relationship of its antiviral, antibacterial and ion channel–modulating activities in the future.
has issue date	2016-04-27(xsd:dateTime)
bibo:doi	10.3390/toxins8050124
bibo:pmid	27128943
has license	cc-by
sha1sum (hex)	0e8773d0887abfa54cb1b618fcdf491e7a0a2c8a
schema:url	https://doi.org/10.3390/toxins8050124
resource representing a document's title	A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro
has PubMed Central identifier	PMC4885039
has PubMed identifier	27128943
schema:publication	Toxins (Basel)
resource representing a document's body	covid:0e8773d0887abfa54cb1b618fcdf491e7a0a2c8a#body_text
is schema:about of	named entity 'viral' named entity 'defensin' named entity 'acute' named entity 'material' named entity 'screened' named entity 'activity' named entity 'Defensin' covid:arg/0e8773d0887abfa54cb1b618fcdf491e7a0a2c8a named entity 'molecule' named entity 'effectively' named entity 'scorpion' named entity 'blocking' named entity 'molecule' named entity 'Here' named entity 'activities' named entity 'Defensins' named entity 'antibacterial' named entity 'problem' named entity 'investigate' named entity 'replication' named entity 'HBV' named entity 'culture medium' named entity 'therapies' named entity 'experimental' named entity 'Virus' named entity 'scorpion' named entity 'interferons' named entity 'defensin' named entity 'viruses' named entity 'HBV' named entity 'HBeAg' named entity 'HBV' named entity 'health problem' named entity 'antibacterial' named entity 'HCC' named entity 'fungi' named entity 'peptides' named entity 'Kv1.3' named entity 'Defensin' named entity 'Hepatitis B Virus' named entity 'hemolysis' named entity 'defensin-like' named entity 'defensin' named entity 'erythrocytes' named entity 'peptides' named entity 'intracellular' named entity 'HBsAg' named entity 'HepG2' named entity 'HepG2' named entity 'peptides' named entity 'genome' named entity 'BioTek' named entity 'wavelength' named entity 'HBV' named entity 'inhibit the growth' named entity 'HBeAg' named entity 'peptides' named entity 'cross-linked' named entity 'erythrocytes' named entity 'inhibitory activity' named entity 'viral polymerase' named entity 'peptides' named entity 'serum' named entity 'down-regulating' named entity 'infection' named entity 'core protein' named entity 'HepG2' named entity 'genome' named entity 'cationic' named entity 'venom' named entity 'MTT assay' named entity 'kDa' named entity 'PMSF' named entity 'HepG2'

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