About: Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protects mice against challenge with SCoV

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About: Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protects mice against challenge with SCoV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protects mice against challenge with SCoV
Creator	Makino, Shinji Yoshikawa-Iwata, Naoko Wang, Nan Lokugamage, Kumari Ito, Naoto Newman, Patrick Tseng, Chien-Te Peters, C Watts, Douglas Wyde, Philip
Source	Elsevier; Medline; PMC
abstract	We tested the efficacy of coronavirus-like particles (VLPs) for protecting mice against severe acute respiratory syndrome coronavirus (SCoV) infection. Coexpression of SCoV S protein and E, M and N proteins of mouse hepatitis virus in 293T or CHO cells resulted in the efficient production of chimeric VLPs carrying SCoV S protein. Balb/c mice inoculated with a mixture of chimeric VLPs and alum twice at an interval of four weeks were protected from SCoV challenge, as indicated by the absence of infectious virus in the lungs. The same groups of mice had high levels of SCoV-specific neutralizing antibodies, while mice in the negative control groups, which were not immunized with chimeric VLPs, failed to manifest neutralizing antibodies, suggesting that SCoV-specific neutralizing antibodies are important for the suppression of viral replication within the lungs. Despite some differences in the cellular composition of inflammatory infiltrates, we did not observe any overt lung pathology in the chimeric-VLP-treated mice, when compared to the negative control mice. Our results show that chimeric VLP can be an effective vaccine strategy against SCoV infection.
has issue date	2008-02-01(xsd:dateTime)
bibo:doi	10.1016/j.vaccine.2007.11.092
bibo:pmid	18191004
has license	bronze-oa
sha1sum (hex)	0e76160729d01c33942105e505724f59a5db1a44
schema:url	https://doi.org/10.1016/j.vaccine.2007.11.092
resource representing a document's title	Chimeric coronavirus-like particles carrying severe acute respiratory syndrome coronavirus (SCoV) S protein protects mice against challenge with SCoV
has PubMed Central identifier	PMC2267761
has PubMed identifier	18191004
schema:publication	Vaccine
resource representing a document's body	covid:0e76160729d01c33942105e505724f59a5db1a44#body_text
is schema:about of	named entity 'CHALLENGE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'efficacy' named entity 'mouse' named entity 'neutralizing antibodies' named entity 'CORONAVIRUS' named entity 'PROTEIN ' named entity 'LEVELS' named entity 'PROTECTING' named entity 'PROTEIN ' named entity 'INFLAMMATORY' named entity 'LIKE' named entity 'BALB' named entity 'COMPARED' named entity 'MICE' named entity 'NEGATIVE CONTROL' named entity 'DID' named entity 'VACCINE' named entity 'INDICATED' covid:arg/0e76160729d01c33942105e505724f59a5db1a44 named entity 'COEXPRESSION' named entity 'ABSENCE OF' named entity 'ALUM' named entity 'LUNG' named entity 'CHALLENGE' named entity 'CORONAVIRUS' named entity 'VLPS' named entity 'CELLULAR' named entity 'MANIFEST' named entity 'INFECTIOUS' named entity 'TWICE' named entity 'COMPOSITION' named entity 'CONTROL GROUPS' named entity 'FAILED' named entity 'PARTICLES' named entity 'CARRYING' named entity 'S PROTEIN' named entity 'LIKE' named entity 'MICE' named entity 'CHIMERIC' named entity 'PROTEINS' named entity 'INTERVAL' named entity 'VIRUS' named entity 'MIXTURE' named entity 'OBSERVE' named entity 'OUR' named entity 'PATHOLOGY' named entity 'INFILTRATES' named entity 'PRODUCTION' named entity 'IMPORTANT' named entity 'CHO CELLS' named entity 'IMMUNIZED' named entity 'NEUTRALIZING ANTIBODIES' named entity 'CHIMERIC' named entity 'MOUSE HEPATITIS VIRUS' named entity 'CARRYING' named entity 'THE LUNGS' named entity 'OVERT' named entity '293T' named entity 'INFECTION' named entity 'VLP' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'S PROTEIN' named entity 'PARTICLES' named entity 'RESULTS' named entity 'STRATEGY' named entity 'SPECIFIC' named entity 'EFFECTIVE' named entity 'HIGH' named entity 'EFFICACY' named entity 'EFFICIENT' named entity 'GROUPS'

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