About: Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection

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About: Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection
Creator	Islam, Abul, Bashar Khademul Islam, Md Khan, Abdullah-Al-Kamran Mir, Abul Mir, Md Rahman Turjya, Rafeed
Source	BioRxiv
abstract	Background Since December 2019, the world is experiencing an unprecedented crisis due to a novel coronavirus, SARS-CoV-2. Owing to poor understanding of pathogenicity, the virus is eluding treatment and complicating recovery. Regulatory roles of long non-coding RNAs (lncRNAs) during viral infection and associated antagonism of host antiviral immune responses has become more evident in last decade. To elucidate possible functions of lncRNAs in the COVID-19 pathobiology, we have utilized RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells. Results Our analyses uncover 21 differentially expressed lncRNAs whose functions are broadly involved in cell survival and regulation of gene expression. By network enrichment analysis we find that these lncRNAs can directly interact with differentially expressed protein-coding genes ADAR, EDN1, KYNU, MALL, TLR2 and YWHAG; and also AKAP8L, EXOSC5, GDF15, HECTD1, LARP4B, LARP7, MIPOL1, UPF1, MOV10 and PRKAR2A, host genes that interact with SARS-CoV-2 proteins. These genes are involved in cellular signaling, metabolism, immune response and RNA homeostasis. Since lncRNAs have been known to sponge microRNAs and protect expression of upregulated genes, we also identified 9 microRNAs that are induced in viral infections; however, some lncRNAs are able to block their usual suppressive effect on overexpressed genes and consequently contribute to host defense and cell survival. Conclusions Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome and this information could drive the search for novel RNA therapeutics as a treatment option.
has issue date	2020-06-29(xsd:dateTime)
bibo:doi	10.1101/2020.06.29.177204
has license	biorxiv
sha1sum (hex)	0e716c5eb2e5f666dc031813f26b657baa71eb7f
schema:url	https://doi.org/10.1101/2020.06.29.177204
resource representing a document's title	Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection
schema:publication	bioRxiv
resource representing a document's body	covid:0e716c5eb2e5f666dc031813f26b657baa71eb7f#body_text
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