About: Clinical and radiological changes of hospitalised patients with COVID-19 pneumonia from disease onset to acute exacerbation: a multicentre paired cohort study

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About: Clinical and radiological changes of hospitalised patients with COVID-19 pneumonia from disease onset to acute exacerbation: a multicentre paired cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical and radiological changes of hospitalised patients with COVID-19 pneumonia from disease onset to acute exacerbation: a multicentre paired cohort study
Creator	Chen, Zhu Yang, Haitao Ma, Cong Yu, Qizhi Chen, Juan Chen, & Liu, Jiayi Cai, Yeyu Chen, Taili Shang, Quan-Liang Xiao, Enhua
Source	Medline; PMC
abstract	OBJECTIVES: To analyse clinical and radiological changes from disease onset to exacerbation in coronavirus infectious disease-19 (COVID-19) patients. METHODS: We reviewed clinical histories of 276 patients with confirmed COVID-19 pneumonia and extracted data on patients who met the diagnostic criteria for COVID-19 severe/fatal pneumonia and had an acute exacerbation starting with mild or common pneumonia. RESULTS: Twenty-four patients were included. Of these, 8% were smokers, 54% had been to Wuhan, and 46% had comorbidities. Before acute exacerbation, elevated lactate dehydrogenase (232.9 ± 88.7) was present, and chest CT scans showed the number of involved lobes was 4 (2–5) and total CT score was 6 (2–8). Following acute exacerbation, patients were likely to have more clinical symptoms (p < 0.01) and abnormal laboratory changes (p < 0.01). The number of involved lobes and CT score after an exacerbation significantly increased to 5 (5–5) and 12 (9–14), respectively. Receiver operating characteristic (ROC) curve showed that, when the cutoff value of CT score was 5, the sensitivity and specificity for severe pneumonia were 90% and 70%, respectively. CT findings of ground glass opacity with consolidations (91.7%), bilateral distribution (100.0%), and multifocal lesion (100.0%) were features in found in patients after exacerbation. CONCLUSIONS: There are significant changes in clinical, laboratory, and CT findings in patients from disease onset to exacerbation. An increase in the number of involved lobes or an increased CT score from the baseline may predict poor clinical outcomes. Combining an assessment of CT changes with clinical and laboratory changes could help clinical teams evaluate the prognosis. KEY POINTS: • The common chest CT signs of COVID-19 pneumonia after exacerbation were ground glass opacity (GGO) with consolidation, bilateral distribution, and multifocal lesions. • An increase in number of involved lobes or an increased CT score from the baseline may predict a poor clinical outcome. • Worsened symptoms and abnormal laboratory results are also associated with poor prognosis.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1007/s00330-020-06916-4
bibo:pmid	32385648
has license	no-cc
sha1sum (hex)	0e4a5db98959ebbf76c61cfe584e518f64be7bda
schema:url	https://doi.org/10.1007/s00330-020-06916-4
resource representing a document's title	Clinical and radiological changes of hospitalised patients with COVID-19 pneumonia from disease onset to acute exacerbation: a multicentre paired cohort study
has PubMed Central identifier	PMC7205907
has PubMed identifier	32385648
schema:publication	Eur Radiol
resource representing a document's body	covid:0e4a5db98959ebbf76c61cfe584e518f64be7bda#body_text
is schema:about of	named entity 'number' named entity 'pneumonia' named entity 'Following' named entity 'COVID-19' named entity 'elevated' named entity 'INCREASE' named entity 'OUTCOME' named entity 'CLINICAL HISTORIES' named entity 'CHANGES' named entity 'WUHAN' named entity 'ABNORMAL' named entity 'onset' named entity 'number' named entity 'pneumonia' named entity 'score' named entity 'laboratory' named entity 'Combining' named entity 'Objectives' named entity 'COVID-19' named entity 'consolidation' named entity 'patients' named entity 'clinical outcome' named entity '0.01' named entity 'Receiver operating characteristic' named entity 'prognosis' named entity 'lactate dehydrogenase' named entity 'clinical outcomes' named entity 'ground glass opacity' named entity 'severe pneumonia' named entity 'COVID' named entity 'pneumonia' named entity 'acute exacerbation' named entity 'bacterial infection' named entity 'Wuhan' named entity 'pneumonia' named entity '0.01' named entity 'dyspnoea' named entity 'COVID' named entity 'comorbidities' named entity 'China' named entity 'IBM Corporation' named entity 'kidney dysfunction' named entity 'albumin' named entity 'Wuhan' named entity 'SPSS' named entity 'COVID' named entity 'chest CT' named entity 'genetic sequence' named entity 'respiratory failure' named entity 'antiviral treatment' named entity 'COVID' named entity 'COVID-19' named entity 'evolution' named entity '0.01' named entity 'risk factors' named entity 'Chest CT' named entity 'epidemiology' named entity 'COVID' named entity 'Disease Control and Prevention' named entity 'GGO' named entity 'Hubei' named entity 'blood urea nitrogen' named entity 'CT scans' named entity 'global health' named entity 'pneumonia' named entity 'pneumonia' named entity 'pneumonia' named entity 'chest CT' named entity 'Medical Ethical' named entity 'coronavirus' named entity 'assay'

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