About: A three-step diagnosis of pediatric pneumonia at the emergency department using clinical predictors, C-reactive protein, and pneumococcal PCR

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About: A three-step diagnosis of pediatric pneumonia at the emergency department using clinical predictors, C-reactive protein, and pneumococcal PCR Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A three-step diagnosis of pediatric pneumonia at the emergency department using clinical predictors, C-reactive protein, and pneumococcal PCR
Creator	Alcoba, Gabriel Keitel, Kristina Galetto-Lacour, Annick Gehri, Mario Gervaix, Alain Ritz, Nicole Lacroix, Laurence Manzano, Sergio Maspoli, Veronica Tabin, René Annick, Annick, Galetto-Lacour Ch,
Source	Medline; PMC
abstract	Recommendations for the management of community-acquired pneumonia (CAP) advocate that, in the absence of the clinical and laboratory findings typical of bacterial CAP, antibiotics are not required. However, the true value of the clinical and laboratory predictors of pediatric CAP still needs to be assessed. This prospective cohort study in three emergency departments enrolled 142 children with radiological pneumonia. Pneumonia with lung consolidation was the primary endpoint; complicated pneumonia (bacteremia, empyema, or pleural effusion) was the secondary endpoint. We showed that three clinical signs (unilateral hypoventilation, grunting, and absence of wheezing), elevated procalcitonin (PCT), C-reactive protein (CRP), negative nasopharyngeal viral PCR, or positive blood pneumococcal PCR (P-PCR) were significantly associated with both pneumonia with consolidation and complicated pneumonia. Children with negative clinical signs and low CRP values had a low probability of having pneumonia with consolidation (13%) or complicated pneumonia (6%). Associating the three clinical signs, CRP >80 mg/L and a positive P-PCR ruled in the diagnosis of complicated pneumonia with a positive predictive value of 75%. Conclusion: A model incorporating clinical signs and laboratory markers can effectively assess the risk of having pneumonia. Children with negative clinical signs and low CRP are at a low risk of having pneumonia. For children with positive clinical signs and high CRP, a positive blood pneumococcal PCR can more accurately confirm the diagnosis of pneumonia.
has issue date	2017-05-04(xsd:dateTime)
bibo:doi	10.1007/s00431-017-2913-0
bibo:pmid	28474099
has license	no-cc
sha1sum (hex)	0e3462773aacc3a0ed8f93b65f26735d532fce23
schema:url	https://doi.org/10.1007/s00431-017-2913-0
resource representing a document's title	A three-step diagnosis of pediatric pneumonia at the emergency department using clinical predictors, C-reactive protein, and pneumococcal PCR
has PubMed Central identifier	PMC7087038
has PubMed identifier	28474099
schema:publication	Eur J Pediatr
resource representing a document's body	covid:0e3462773aacc3a0ed8f93b65f26735d532fce23#body_text
is schema:about of	named entity 'EMERGENCY DEPARTMENT' named entity 'PNEUMONIA' named entity 'pneumonia' named entity 'complicated' named entity 'pneumonia' named entity 'clinical signs' named entity 'POSITIVE PREDICTIVE VALUE' named entity 'ADVOCATE' named entity 'EMPYEMA' named entity 'ELEVATED' named entity 'POSITIVE' named entity 'NASOPHARYNGEAL' named entity 'PROBABILITY OF' named entity 'PNEUMOCOCCAL' named entity 'USING' named entity 'PNEUMOCOCCAL' named entity 'VALUE' named entity 'VALUES' named entity 'PCR' named entity 'GRUNTING' named entity 'MG%' named entity 'NEEDS' named entity 'PEDIATRIC' named entity 'ASSOCIATED WITH' named entity 'PEDIATRIC' covid:arg/0e3462773aacc3a0ed8f93b65f26735d532fce23 named entity 'DIAGNOSIS' named entity 'PCR' named entity 'COMPLICATED' named entity 'MANAGEMENT' named entity 'CAP' named entity 'STEP' named entity 'C-REACTIVE PROTEIN' named entity 'CLINICAL' named entity 'RECOMMENDATIONS' named entity '28P' named entity 'ASSESSED' named entity 'LOW PROBABILITY' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'DIAGNOSIS' named entity 'NEGATIVE' named entity 'PNEUMONIA' named entity 'BACTERIAL' named entity 'EMERGENCY' named entity 'WHEEZING' named entity 'CONSOLIDATION' named entity 'TYPICAL' named entity 'VIRAL' named entity 'CLINICAL' named entity 'LABORATORY' named entity 'FINDINGS' named entity 'BLOOD' named entity 'TRUE' named entity 'LUNG CONSOLIDATION' named entity 'ABSENCE OF' named entity 'PRIMARY ENDPOINT' named entity 'HYPOVENTILATION' named entity 'CHILDREN' named entity 'ANTIBIOTICS' named entity 'PROSPECTIVE COHORT STUDY' named entity 'CRP' named entity 'C-REACTIVE PROTEIN' named entity 'PLEURAL EFFUSION' named entity 'PROCALCITONIN' named entity 'LOW' named entity 'SECONDARY ENDPOINT' named entity 'PROTEIN ' named entity 'ENROLLED' named entity 'NOT REQUIRED'

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