About: Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

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About: Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection
Creator	Yoshikawa, Tomoki Popov, Vsevolod Hill, Terence Yoshikawa, Naoko Morty, Rory Peters, C Galindo, Cristi Garner, Harold Tseng, Kent
Source	Medline; PMC
abstract	Human lung epithelial cells are likely among the first targets to encounter invading severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Not only can these cells support the growth of SARS-CoV infection, but they are also capable of secreting inflammatory cytokines to initiate and, eventually, aggravate host innate inflammatory responses, causing detrimental immune-mediated pathology within the lungs. Thus, a comprehensive evaluation of the complex epithelial signaling to SARS-CoV is crucial for paving the way to better understand SARS pathogenesis. Based on microarray-based functional genomics, we report here the global gene response of 2B4 cells, a cloned bronchial epithelial cell line derived from Calu-3 cells. Specifically, we found a temporal and spatial activation of nuclear factor (NF)κB, activator protein (AP)-1, and interferon regulatory factor (IRF)-3/7 in infected 2B4 cells at 12-, 24-, and 48-hrs post infection (p.i.), resulting in the activation of many antiviral genes, including interferon (IFN)-β, -λs, inflammatory mediators, and many IFN-stimulated genes (ISGs). We also showed, for the first time, that IFN-β and IFN-λs were capable of exerting previously unrecognized, non-redundant, and complementary abilities to limit SARS-CoV replication, even though their expression could not be detected in infected 2B4 bronchial epithelial cells until 48 hrs p.i. Collectively, our results highlight the mechanics of the sequential events of antiviral signaling pathway/s triggered by SARS-CoV in bronchial epithelial cells and identify novel cellular targets for future studies, aiming at advancing strategies against SARS.
has issue date	2010-01-15(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0008729
bibo:pmid	20090954
has license	cc-by
sha1sum (hex)	0e23b62f7dca85c31f4f90603d2a28dfc7177947
schema:url	https://doi.org/10.1371/journal.pone.0008729
resource representing a document's title	Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection
has PubMed Central identifier	PMC2806919
has PubMed identifier	20090954
schema:publication	PLoS One
resource representing a document's body	covid:0e23b62f7dca85c31f4f90603d2a28dfc7177947#body_text
is schema:about of	named entity 'Innate' named entity 'signaling' named entity 'signaling pathway' named entity 'triggered' named entity 'antiviral' named entity 'Human' named entity 'Bronchial' named entity 'Infection' named entity 'RESULTING IN' named entity 'INFLAMMATORY' named entity 'CORONAVIRUS' named entity 'EXERTING' named entity 'SIGNALING PATHWAY' named entity 'HUMAN LUNG' named entity 'GENE RESPONSE' named entity 'DYNAMIC' named entity 'INTERFERON REGULATORY FACTOR' named entity 'INFECTED' named entity 'SECRETING' named entity 'PROTEIN ' named entity 'NUCLEAR' named entity 'CELLULAR' named entity 'STUDIES' named entity 'CELLS' named entity 'IMMUNE RESPONSES' named entity 'EPITHELIAL CELLS' named entity '28P' named entity 'BASED' named entity 'SARS' named entity 'OUR' named entity 'CITATION' named entity 'FACTOR' named entity 'WAY' named entity 'INITIATE' named entity 'GALINDO' named entity 'ADVANCING' named entity 'ASSOCIATED' named entity 'GENES' named entity 'THESE' named entity 'ANTIVIRAL' named entity 'GLOBAL' named entity 'FOUND' named entity 'CLONED' named entity 'INFLAMMATORY MEDIATORS' named entity 'FUNCTIONAL GENOMICS' named entity 'SEVERE' named entity 'PREVIOUSLY' named entity 'DETECTED' named entity 'IDENTIFY' named entity 'SARS-COV INFECTION' named entity 'CORONAVIRUS INFECTION' named entity 'CALU-3' named entity 'IFN' named entity 'GROWTH' named entity 'ABILITIES' named entity 'BUT' named entity 'RESULTS' named entity 'TIME' named entity 'LIKELY' named entity 'HERE' named entity 'IMMUNE RESPONSES' named entity 'HUMAN' named entity 'ASSOCIATED' named entity 'CYTOKINES' named entity 'INTERFERON ' named entity 'PATHOLOGY' named entity 'ACTIVATOR' named entity 'SUPPORT' named entity 'ACUTE' named entity 'EVALUATION' named entity 'COMPLEX' named entity 'REPORT' named entity 'STIMULATED'

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