About: Development of a novel DNA microarray to detect bacterial pathogens in patients with chronic obstructive pulmonary disease (COPD)

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About: Development of a novel DNA microarray to detect bacterial pathogens in patients with chronic obstructive pulmonary disease (COPD) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Development of a novel DNA microarray to detect bacterial pathogens in patients with chronic obstructive pulmonary disease (COPD)
Creator	Curran, Tanya Kidney, Joe Larkin, Mike Coulter, Wilson Coyle, Peter Fairley, Derek Mcmanus, Terence Moore, John
Source	Elsevier; Medline; PMC
abstract	Abstract A novel microarray was constructed with DNA PCR product probes targeting species specific functional genes of nine clinically significant respiratory pathogens, including the Gram-positive organisms (Streptococcus pneumoniae, Streptococcus pyogenes), the Gram-negative organisms (Chlamydia pneumoniae, Coxiella burnetii Haemophilus spp., Legionella pneumophila, Moraxella catarrhalis, and Pseudomonas aeruginosa), as well as the atypical bacterium, Mycoplasma pneumoniae. In a “proof-of-concept” evaluation of the developed microarray, the microarray was compared with real-time PCR from 14 sputum specimens from COPD patients. All of the samples positive for bacterial species in real-time PCR were also positive for the same bacterial species using the microarray. This study shows that a microarray using PCR probes is a potentially useful method to monitor the populations of bacteria in respiratory specimens and can be tailored to specific clinical needs such as respiratory infections of particular patient populations, including patients with cystic fibrosis and bronchiectasis.
has issue date	2010-03-31(xsd:dateTime)
bibo:doi	10.1016/j.mimet.2010.01.004
bibo:pmid	20074591
has license	els-covid
sha1sum (hex)	0dfe43246f99164a436ae3b7cb334e645a0532ba
schema:url	https://doi.org/10.1016/j.mimet.2010.01.004
resource representing a document's title	Development of a novel DNA microarray to detect bacterial pathogens in patients with chronic obstructive pulmonary disease (COPD)
has PubMed Central identifier	PMC7132519
has PubMed identifier	20074591
schema:publication	Journal of Microbiological Methods
resource representing a document's body	covid:0dfe43246f99164a436ae3b7cb334e645a0532ba#body_text
is schema:about of	named entity 'microarray' named entity 'respiratory infections' named entity 'samples' named entity 'populations' named entity 'specific' named entity 'Mycoplasma pneumoniae' named entity 'respiratory' named entity 'TO DETECT' named entity 'IS A' named entity 'SAMPLES' named entity 'PARTICULAR' named entity 'CLINICAL' named entity 'NOVEL' named entity 'METHOD' named entity 'USING' named entity 'BRONCHIECTASIS' named entity 'SPP' named entity 'MORAXELLA CATARRHALIS' named entity 'RESPIRATORY PATHOGENS' named entity 'COMPARED' named entity 'CONCEPT' named entity 'TARGETING' named entity 'STREPTOCOCCUS PYOGENES' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'EVALUATION' named entity 'SPUTUM' named entity 'PCR' named entity 'BACTERIA ' named entity 'RESPIRATORY INFECTIONS' named entity 'CONSTRUCTED' named entity 'PATIENTS' named entity 'BACTERIAL PATHOGENS' named entity 'DNA MICROARRAY' named entity 'DEVELOPMENT' named entity 'NOVEL' named entity 'HAEMOPHILUS' named entity 'PNEUMONIAE' named entity 'PCR PRODUCT' named entity 'CYSTIC FIBROSIS' named entity 'LEGIONELLA PNEUMOPHILA' named entity 'MICROARRAY' named entity 'GRAM-' named entity 'NEGATIVE' named entity 'COXIELLA BURNETII' named entity 'MONITOR' named entity 'BACTERIAL' named entity 'TAILORED' named entity 'SIGNIFICANT' named entity 'SPECIES' named entity 'MYCOPLASMA PNEUMONIAE' named entity 'COPD' named entity 'PATIENT' named entity 'ORGANISMS' named entity 'OF-' named entity 'PSEUDOMONAS AERUGINOSA' named entity 'POSITIVE' named entity 'POPULATIONS' named entity 'STUDY' named entity 'REAL-TIME PCR ' named entity 'USEFUL' named entity 'PATIENTS' named entity 'INCLUDING' named entity 'DNA' named entity 'RESPIRATORY' named entity 'PROBES' named entity 'ATYPICAL' named entity 'SPECIFIC' named entity 'FUNCTIONAL GENES' named entity 'BACTERIUM' named entity 'SPECIMENS' named entity 'NEEDS' named entity 'respiratory' named entity 'species' named entity 'organisms'

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