About: Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice
Source	PMC
abstract	We have recently found that combination of ovariectomy (OVX) and chronic restraint stress causes cognitive dysfunction and reduces hippocampal CA3 neurons in female rats and mice and that estrogen replacement and chronic treatment with Ginkgo biloba extract EGb 761 suppress the OVX/stress-induced behavioral and morphological changes. In this study, we examined the effect of placental extract on the memory impairment and neuromorphological change in OVX/stress-subjected mice. Female Slc:ICR strain mice were randomly divided into four groups: vehicle-treated OVX, porcine placental extract (120 and 2160 mg/kg)-treated OVX, and sham-operated control groups. Two weeks after surgical operation, OVX mice underwent restraint stress for 21 days (6 h/day), and all animals were then subjected to a contextual fear conditioning test followed by morphological examination by Nissl staining. Placental extract was orally administered once daily until the behavioral analysis was carried out. Chronic treatment with both doses of placental extract improved the OVX/stress-induced fear memory impairment and Nissl-positive cell loss of the hippocampal CA3 region, although it did not affect the loss of bone mineral density and increase in body weight after OVX. These results have important implications for the neuroprotective and cognition-enhancing effects of placental extract in postmenopausal women.
has issue date	2019-06-11(xsd:dateTime)
bibo:doi	10.1254/jphs.12115fp
bibo:pmid	22971911
has license	no-cc
sha1sum (hex)	0de937d290fa62a35fd2efc71b9db077dcc1c989
schema:url	https://doi.org/10.1254/jphs.12115fp
resource representing a document's title	Placental Extract Improves Hippocampal Neuronal Loss and Fear Memory Impairment Resulting From Chronic Restraint Stress in Ovariectomized Mice
has PubMed Central identifier	PMC7128920
has PubMed identifier	22971911
schema:publication	J Pharmacol Sci
resource representing a document's body	covid:0de937d290fa62a35fd2efc71b9db077dcc1c989#body_text
is schema:about of	named entity 'mice' named entity 'multiple comparison' named entity 'PBS' named entity 'control groups' named entity 'porcine' named entity 'rodents' named entity 'mice' named entity 'statistical significance' named entity 'memory impairment' named entity 'estrogen' named entity 'sham-operated' named entity 'body weight' named entity 'paraformaldehyde' named entity 'memory deficits' named entity 'Body weight' named entity 'multigroup' named entity 'hormones' named entity 'microtome' named entity 'bioactive molecules' named entity 'conditioned stimulus' named entity 'neuronal loss' named entity 'sham-operated' named entity 'memory loss' named entity 'one-way ANOVA' named entity 'paraformaldehyde' named entity 'placental' named entity 'Kanazawa University' named entity 'placental' named entity 'estrogens' named entity 'memory deficits' named entity 'body weight' named entity 'hydrophobic' named entity 'PBS' named entity 'multiple comparison' named entity 'mice' named entity 'estrogen' named entity 'mice' named entity 'brain-derived neurotrophic factor' named entity 'hippocampus' named entity 'mice' named entity 'United States National Institutes of Health' named entity 'cognitive enhancer' named entity 'uterine weight' named entity 'placental' named entity 'mice' named entity 'CA3' named entity 'perfusion' named entity 'Alkam' named entity 'dentate gyrus' named entity 'microscope' named entity 'animal studies' named entity 'memory problems' named entity 'plastic' named entity 'CA3' named entity 'response to stress' named entity 'fatigue' named entity 'placental' named entity 'CA3' named entity 'protease' named entity 'placental' named entity 'innervation' named entity 'menopausal' named entity 'mice' named entity 'placental' named entity 'peptides' named entity 'glycosaminoglycans' named entity 'uterine weight' named entity 'mice' named entity 'estrogens' named entity 'skin disorders' named entity 'growth factors' named entity 'fibroblast growth factor' named entity 'CA3' named entity 'saline' named entity 'bone mineral density' named entity 'neuronal cell' named entity 'significant difference' named entity 'femur' named entity 'pyramidal neurons' named entity 'light cycle' named entity 'placental' named entity 'hormone replacement therapy'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software