About: Enteropathy associated T cell lymphoma in celiac disease: A large retrospective study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Enteropathy associated T cell lymphoma in celiac disease: A large retrospective study
Creator	Allez, Matthieu Berger, Anne Bouhnik, Yoram Brousse, Nicole Callens, Céline Cellier, Christophe Cerf-Bensussan, Nadine Chandesris, Olivia Châtellier, Gilles Gornet, Jean-Marc Hermine, Olivier Jian, Raymond Macintyre, Elizabeth Malamut, Georgia Meresse, Bertrand Verkarre, Virginie
source	Elsevier; Medline; PMC
abstract	Abstract Introduction Prognosis of enteropathy-associated T cell lymphoma is poor but predictors of survival remain ill-defined. How clinical presentation, pathological features and therapies influence outcome was evaluated in 37 thoroughly characterized patients with celiac disease and T-cell lymphoma. Patients and methods Medical files were studied retrospectively. Lymphoma and intestinal mucosa were analysed by histopathology, multiplex PCR and intestinal intraepithelial lymphocytes phenotyping. Survival and prognostic factors were analysed using Kaplan–Meier curves with Logrank test and Cox Model. Results Lymphoma complicated non clonal enteropathy, celiac disease (n =15) and type I refractory celiac disease (n =2) in 17 patients and clonal type II refractory celiac disease in 20 patients. Twenty-five patients underwent surgery with resection of the main tumour mass in 22 cases. In univariate analysis, non clonal celiac disease, serum albumin level>21.6g/L at diagnosis, chemotherapy and surgical resection predicted good survival (p =0.0007, p <0.0001, p <0.0001, p <0.0001, respectively). In multivariate analysis, serum albumin level>21.6g/L, chemotherapy and reductive surgery were all significantly associated with increased survival (p <0.002, p <0.03, p <0.03, respectively). Conclusions Our study underlines the prognostic value of celiac disease type in patients with T-cell lymphoma, and suggests that a combination of nutritional, chemotherapy and reductive surgery may improve survival.
has issue date	2013-05-31(xsd:dateTime)
bibo:doi	10.1016/j.dld.2012.12.001
bibo:pmid	23313469
has license	els-covid
sha1sum (hex)	0d943213b7067c93e38073661b3237be2e370261
schema:url	https://doi.org/10.1016/j.dld.2012.12.001
resource representing a document's title	Enteropathy associated T cell lymphoma in celiac disease: A large retrospective study
has PubMed Central identifier	PMC7185558
has PubMed identifier	23313469
schema:publication	Digestive and Liver Disease
resource representing a document's body	covid:0d943213b7067c93e38073661b3237be2e370261#body_text
is schema:about of	named entity 'analysed' named entity 'nutritional' named entity 'Introduction' named entity 'serum albumin' named entity 'good' named entity 'resection' named entity 'MAIN' named entity 'CHEMOTHERAPY' named entity 'PREDICTED' named entity 'T-CELL LYMPHOMA' named entity 'AT DIAGNOSIS' named entity 'TYPE I' named entity 'SURGERY' named entity 'PATHOLOGICAL FEATURES' named entity 'INTESTINAL MUCOSA' named entity 'CONCLUSIONS' named entity 'SURGICAL RESECTION' named entity 'COMBINATION' named entity 'CASES' named entity 'NUTRITIONAL' named entity 'PROGNOSIS' named entity 'GOOD' covid:arg/0d943213b7067c93e38073661b3237be2e370261 named entity 'HISTOPATHOLOGY' named entity 'STUDY' named entity 'LYMPHOMA' named entity 'PHENOTYPING' named entity 'UNIVARIATE ANALYSIS' named entity 'USING' named entity 'REDUCTIVE' named entity 'CELIAC DISEASE' named entity 'MEDICAL' named entity 'CLONAL' named entity 'MULTIVARIATE ANALYSIS' named entity 'PROGNOSTIC FACTORS' named entity 'TWENTY-FIVE' named entity 'TEST' named entity 'NON' named entity 'RETROSPECTIVE STUDY' named entity 'INFLUENCE' named entity 'ENTEROPATHY ASSOCIATED T CELL LYMPHOMA' named entity 'CELIAC DISEASE' named entity '28P' named entity 'RESULTS' named entity 'SURVIVAL' named entity 'TYPE II' named entity 'MULTIPLEX PCR' named entity 'REFRACTORY CELIAC DISEASE' named entity 'ASSOCIATED WITH' named entity 'PROGNOSTIC VALUE' named entity 'COMPLICATED' named entity 'THERAPIES' named entity 'POOR' named entity 'LARGE' named entity 'EVALUATED' named entity 'DISEASE TYPE' named entity 'CHARACTERIZED' named entity '0.03' named entity 'OUTCOME' named entity 'HOW' named entity 'COX MODEL' named entity 'METHODS' named entity 'PATIENTS' named entity 'OUR' named entity 'INTRAEPITHELIAL LYMPHOCYTES' named entity 'INTESTINAL'

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