About: Steroid‐responsive encephalitis in Covid‐19 disease

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About: Steroid‐responsive encephalitis in Covid‐19 disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Steroid‐responsive encephalitis in Covid‐19 disease
Creator	Castelli, Francesco Zetterberg, Henrik Focà, Emanuele Ashton, Nicholas Blennow, Kaj Caruso, Arnaldo Comelli, Agnese Gasparotti, Roberto Gazzina, Stefano Leonardi, Matilde Masciocchi, Stefano Nocivelli, Sara Odolini, Silvia Padovani, Alessandro Pasolini, Maria Pezzini, Pilotto, Andrea Psy, Alessandro Volonghi, Irene
Source	Medline; PMC
abstract	Covid‐19 infection has the potential for targeting the central nervous system and several neurological symptoms have been described in patients with severe respiratory distress. Here we described the case of a 60‐year old subject with SARS‐CoV‐2 infection but only mild respiratory abnormalities who developed an akinetic mutism due to encephalitis. MRI was negative whereas EEG showed generalized theta slowing. CSF analyses during the acute stage were negative for SARS‐CoV‐2, positive for pleocytosis and hyperproteinorrachia, and showed increased IL‐8 and TNF‐α concentrations while other infectious or autoimmune disorders were excluded. A progressive clinical improvement along with a reduction of CSF parameters was observed after high‐dose steroid treatment, thus arguing for an inflammatory‐mediated brain involvement related to Covid‐19. This article is protected by copyright. All rights reserved.
has issue date	2020-05-17(xsd:dateTime)
bibo:doi	10.1002/ana.25783
bibo:pmid	32418288
has license	no-cc
sha1sum (hex)	0d2ef48a0b17f56cf8494fe49f0b6d9643c03a7b
schema:url	https://doi.org/10.1002/ana.25783
resource representing a document's title	Steroid‐responsive encephalitis in Covid‐19 disease
has PubMed Central identifier	PMC7276848
has PubMed identifier	32418288
schema:publication	Ann Neurol
resource representing a document's body	covid:0d2ef48a0b17f56cf8494fe49f0b6d9643c03a7b#body_text
is schema:about of	named entity 'targeting' named entity 'autoimmune disorders' named entity 'patients' named entity 'positive' named entity 'Covid-19' named entity 'subject' named entity 'excluded' named entity 'infection' named entity 'CSF' named entity 'respiratory distress' named entity 'infection' named entity 'Covid-19' named entity 'respiratory distress' named entity 'Covid' named entity 'MRI' named entity 'SARS-CoV-2' named entity 'autoimmune disorders' named entity 'CSF' named entity 'steroid' named entity 'SARS-CoV-2' named entity 'Chest x-ray' named entity 'disinhibition' named entity 'akinetic mutism' named entity 'interstitial pneumonia' named entity 'neurological examination' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'pleocytosis' named entity 'encephalitis' named entity 'Ethics Commission' named entity 'interleukin 8' named entity 'HSV' named entity 'central nervous' named entity 'mediated response' named entity 'steroid' named entity 'MRI' named entity 'HSV-2' named entity 'chemokines' named entity 'fever' named entity 'oligoclonal bands' named entity 'SARS-CoV-2' named entity 'arterial partial pressure of oxygen' named entity 'autoimmune' named entity 'nasopharyngeal swab' named entity 'neuronal network' named entity 'respiratory function' named entity 'blood cell counts' named entity 'magnetic resonance imaging' named entity 'intravenous' named entity 'Covid' named entity 'simple tasks' named entity 'neurotropism' named entity 'ethics committee' named entity 'neurological' named entity 'infection' named entity 'akinetic mutism' named entity 'SARS-CoV-2' named entity 'cytokines' named entity 'Covid' named entity 'Epidemiological studies' named entity 'cytokine' named entity 'steroid' named entity 'asthenia' named entity 'COVID-19'

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