About: Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19
Creator	Li, Man Liu, Zeming Zeng, Wen Wang, Xinghuan Guo, Liang Long, Wei Chen, Danyang Chen, Sichao Huang, Yihui Gao, Rongfen Huang, Jianglong Li, Jinpeng Wu, Xiaohui
Source	Medline; PMC
abstract	BACKGROUND: Interleukin-6 (IL-6), a proinflammatory cytokine, has been reported to be associated with disease severity and mortality in patients with coronavirus disease 2019 (COVID-19). Yet, dynamic changes in IL-6 levels and their prognostic value as an indicator of lung injury in COVID-19 patients have not been fully elucidated. OBJECTIVE: To validate whether IL-6 levels are associated with disease severity and mortality and to investigate whether dynamic changes in IL-6 levels might be a predictive factor for lung injury in COVID-19 patients. METHODS: This retrospective, single-center study included 728 adult COVID-19 patients and used data extracted from electronic medical records for analyses. RESULTS: The mortality rate was higher in the elevated IL-6 group than in the normal IL-6 group (0.16 vs 5%). Cox proportional hazards and logistic regression analyses for survival (adjusted hazard ratio, 10.39; 95% confidence interval [CI], 1.09–99.23; p = 0.042) and disease severity (adjusted odds ratio, 3.56; 95% CI, 2.06–6.19; p < 0.001) revealed similar trends. Curve-fitting analyses indicated that patient computed tomography (CT) scores peaked on days 22 and 24. An initial decline in IL-6 levels on day 16 was followed by resurgence to a peak, nearly in tandem with the CT scores. CONCLUSION: Increased IL-6 level may be an independent risk factor for disease severity and in-hospital mortality and dynamic IL-6 changes may serve as a potential predictor for lung injury in Chinese COVID-19 patients. These findings may guide future treatment of COVID-19 patients.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.3389/fphar.2020.01093
bibo:pmid	32765283
has license	cc-by
sha1sum (hex)	0ceb60fcf5e46e1f48e02c44d0cc25f88d366e62
schema:url	https://doi.org/10.3389/fphar.2020.01093
resource representing a document's title	Dynamic Interleukin-6 Level Changes as a Prognostic Indicator in Patients With COVID-19
has PubMed Central identifier	PMC7379481
has PubMed identifier	32765283
schema:publication	Front Pharmacol
resource representing a document's body	covid:0ceb60fcf5e46e1f48e02c44d0cc25f88d366e62#body_text
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